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Respiratory system response to local cooling in subjects with single nucleotide polymorphism rs11562975 of the TRPM8 temperature-sensitive ion channel gene

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Abstract

Genome studies in ethnic Russians revealed subjects having a heterozygous genotype with allele C at the single-nucleotide polymorphism rs11562975 (G → C), which is in exon 6 of the TRPM8 temperature-sensitive ion channel gene. The subjects had increased sensitivity to cold and produced a hypometabolic response to local skin cooling and to temperature-independent activation of the TRPM8 ion channel by menthol, including a decrease in gas exchange, pulmonary ventilation, and oxygen extraction coefficient. Subjects with the homozygous genotype GG had a lower sensitivity to cold, and their response to local skin cooling was adequate in terms of thermoregulation, including a decrease in respiratory heat loss and an increase in lipid metabolism.

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Authors and Affiliations

  1. Institute of Physiology and Fundamental Medicine, Siberian Branch, Russian Academy of Medical Sciences, Novosibirsk, Russia

    T. V. Kozyreva & E. Ya. Tkachenko

  2. Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

    T. A. Potapova & M. I. Voevoda

  3. Institute of Therapy, Siberian Branch, Russian Academy of Medical Sciences, Novosibirsk, Russia

    M. I. Voevoda

Authors
  1. T. V. Kozyreva
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  2. E. Ya. Tkachenko
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  3. T. A. Potapova
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  4. M. I. Voevoda
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Original Russian Text © T.V. Kozyreva, E.Ya. Tkachenko, T.A. Potapova, M.I. Voevoda, 2014, published in Fiziologiya Cheloveka, 2014, Vol. 40, No. 2, pp. 94–98.

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Kozyreva, T.V., Tkachenko, E.Y., Potapova, T.A. et al. Respiratory system response to local cooling in subjects with single nucleotide polymorphism rs11562975 of the TRPM8 temperature-sensitive ion channel gene. Hum Physiol 40, 197–200 (2014). https://doi.org/10.1134/S0362119714020108

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  • DOI: https://doi.org/10.1134/S0362119714020108

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