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New approaches in the study of the neuroplasticity process in patients with central nervous system lesions

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Abstract

Methods that, on the one hand, can ensure patient’s mobility and, on the other hand, activate afferent inputs are the main in the rehabilitation treatment. Recent studies have shown that plasticity is the structural basis of recovery after central nervous system lesions. Reorganization of cortical areas, increase in the efficiency of the functioning of preserved structures; and active use of alternative ascending pathways, e.g., intensification of afferent input, constitute the anatomical basis of plasticity. However, sensory correction methods, without accounting of functional condition of patients, may lead to the formation of pathological symptoms: spasticity, hyperreflexia, etc. So, the main aim is to study adequate management of the neuroplasticity process. This problem cannot be solved without modern methods of neuroimaging and brain mapping. The new approach for the study of cortical mechanisms of neuroplasticity, responsible for locomotion, was developed in the present study. This approach is an integrated use of functional magnetic resonance imaging (fMRI) and navigation transcranial magnetic stimulation (nTMS). It has been shown that vast fMRI activation area in the first and second sensorimotor areas emerges with a passive sensorimotor paradigm usage that imitates backing load during walking. The Korvit mechanical stimulator of backing zones of footsteps is used to create this paradigm. The nTMS examination used after fMRI helps to localize motor representation of muscles which control locomotion more accurately. We assume that the new approach can be used for studying the neuroplasticity process and assessing neuroplasticity changes when taking rehabilitation measures to restore and correct the walking process.

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Authors and Affiliations

  1. Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, 125367, Russia

    L. A. Chernikova, E. I. Kremneva, A. V. Chervyakov, R. N. Konovalov & M. A. Piradov

  2. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, 123007, Russia

    I. V. Saenko & I. B. Kozlovskaya

Authors
  1. L. A. Chernikova
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  2. E. I. Kremneva
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  3. A. V. Chervyakov
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  4. I. V. Saenko
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  5. R. N. Konovalov
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  6. M. A. Piradov
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  7. I. B. Kozlovskaya
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Chernikova, L.A., Kremneva, E.I., Chervyakov, A.V. et al. New approaches in the study of the neuroplasticity process in patients with central nervous system lesions. Hum Physiol 39, 272–277 (2013). https://doi.org/10.1134/S0362119713030055

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