Abstract
In the period from 2000 to 2012, the values of 40 diagnostically significant biochemical indices in venous blood were determined during the preflight clinical and physiological examination of 28 Russian cosmonauts aged 35 to 54, members of the main and backup crews of missions on board the International Space Station. The examination was conducted 45-30 days prior to the launch. Since most cosmonauts performed several flights during this period and they were repeatedly included in backup crews, each of the cosmonauts participated in preflight examinations one to five times. The reference values were calculated for each of the studied indices. It was found that reference interval boundaries for 15 indices were narrower as compared to the generally accepted ranges. The upper boundaries of the reference ranges of the activities of a number of enzymes, as well as of the concentrations of some metabolites of energy and plasticity metabolism, were higher than the population’s mean values. Thus, it was found that Russian cosmonauts, being a specific professional team, had reference values of a number of blood biochemical indices that were different from the population’s mean values. This was due to the characteristics of selection, physical training, and psychic and emotional states of crew members during the preflight period.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Markin, A.A. and Zhuravleva, O.A., Biochemical Blood Study, in Orbital’naya stantsiya “Mir” (Mir Orbital Station), Moscow, 2002, vol. 1.
Markin, A.A., Morukov, B.V., and Zhuravleva, O.A., Biochemical Status of Human After Space Flight, in Mezhdunarodnaya kosmicheskaya stantsiya. Rossiiskii segment. Kosmicheskaya biologiya i meditsina (International Space Station. Russian Segment. Space Biology and Medicine), Moscow, 2011, vol. 2, p. 197.
Sokolov, V.V., Gus’kova, A.K., and Gribova, I.A., On Study of the Norm in Medicine, Vestn. Akad. Med. Nauk SSSR, 1975, no. 5, p. 40.
Men’shikov, V.V. and Pimenova, L.M., Metodicheskie rekomendatsii po razrabotke referentnykh velichin laboratornykh pokazatelei (Methodical Recommendations for Elaboration of Reference Magnitudes of Laboratory Indices), Moscow: MZ SSSR, 1983.
How to Define and Determine Reference Intervals in the Clinical Laboratory: Approved Guideline, 2nd Ed., CLSI Document C28-A2. Wayne: CLSI, 2000.
Vetrova, E.G., Activity of Dehydrogenasees of Blood Serum at the Impact of Space Flight Factors, Cand. Sci. (Med.) Dissertation, Moscow, 1990.
Kamyshnikov, V.S., Spravochnik po kliniko biokhimicheskim issledovaniyam i laboratornoi diagnos tike (Guide for ClinicalBiochemical Studies and Laboratiry Diagnostics), Moscow, 2004.
Rosalki, S.B. and Foo, A.Y., Two New Methods for Separating and Quantifying Bone and Liver Alcaline Phosphatase Isoenzymes in Plasma, Clin. Chem., 1984, vol. 30, no. 7, p. 1182.
Kamyshnikov, V.S., Klinicheskie laboratornye testy ot A do Ya i ikh diagnosticheskie profili (Clinical Laboratory Tests from A to Z and Their Diagnostic Profiles), Moscow, 2009.
Glants, S., Medikobiologicheskaya statistika (Biomed ical Statistics), Moscow, 1998 (Tr. Eng.)
Everitt, B.S., Medical Statistics from A to Z, Cambridge, 2006.
Gorchakova, N.A., Gudivok, Ya.S., Gunina, L.M., et al., Farmakologiya sporta (Sports Pharmacology), Kiev, 2010.
Wayer, R., Collins, J., Noble, E.G., and Taylor, A.W., A Decade of Aerobic Endurance Training: Histological Evidence for Fibre Type Transformation, Sports Med. Phys. Fitness, 2000, vol. 40, no. 4, p. 284.
Kudryashova, E.V., Bronza, V.L., and Levashov, A.V., The Effect of Lipids on the Catalytic Activity of Acid Phosphatase in the System of Inverted Micells, Biokhimiya, 2009, vol. 74, no. 3, p. 342.
Marshall, W.J., Clinical Biochemistry, London: Churchill Livingstone, 1995.
Liseum, L. and Muhn, N.J., Intracellular Cholesterol Transport, Biochim. Biophys. Acta, 1999, vol. 1438, no. 1, p. 19.
Baraboi, V.A., Bioantioksidanty (Bioantioxidants), Kiev, 2006.
Author information
Authors and Affiliations
Additional information
Original Russian Text © A.A. Markin, O.A. Zhuravleva, B.V. Morukov, D.S. Kuzichkin, I.V. Zabolotskaya, L.V. Vostrikova, 2013, published in Fiziologiya Cheloveka, 2013, Vol. 39, No. 2, pp. 79–84.
Rights and permissions
About this article
Cite this article
Markin, A.A., Zhuravleva, O.A., Morukov, B.V. et al. Reference values of blood biochemical indices in Russian cosmonauts. Hum Physiol 39, 178–183 (2013). https://doi.org/10.1134/S0362119713020084
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0362119713020084