Skip to main content
SpringerLink
Log in

Some aspects of the comparative analysis of hemodynamic responses to LBNP tests in cosmonauts of different age groups

  • Experimental and General Theoretical Studies
  • Published:
Human Physiology Aims and scope Submit manuscript

Abstract

The age-specific indicators of the functions of the cardiovascular system and its responses to the lower body negative pressure (LBNP) test were studied in career cosmonauts for the first time. The results of 174 LBNP tests implemented within the standard medical monitoring program on board the “Mir” orbital station (OS “Mir”), using a Gamma-01 device, and aboard the International Space Station (ISS), using the Gamma-1M complex, were subjected to comparative analysis. In total, 38 cosmonauts from 25 long-duration space missions on board the “Mir” OS and ISS, who were examined in their pre-flight state and during in-flight periods, beginning, typically, on flight day (FD) 120, were subdivided into two age groups: 30- to 39-year-olds (their mean age was 36 ± 0.7 years; 39% of the total number of subjects) and 40- to 55-year olds (their mean age was 46 ± 0.8 years; 61% of the total number of subjects). We have revealed age-specific indicators for the hemodynamic status recorded at each stage of the investigation: at rest in a preflight state; responses of the indicators to the effects of microgravity; the relative dynamics of the indicators due to a simulated orthostatic posture, which was unidirectional but substantially different at the pre-and in-flight stages. For purposes of medical control, our results have shown that we need to establish age-specific references in our methodical approaches to the analysis and interpretation of the data received from monitoring cosmonauts’ health in their preflight state and during the entire mission and, which is particularly important in practical terms, when evaluating the LBNP test intolerance at different flight stages.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Alferova, I.V., Turchaninova, V.F., Golubchikova, Z.A., et al., The Functional State of the Cardiovascular System at Rest in the Cosmonauts of the 1st–22nd Main Expeditions before and in Long-Duration Space Flights, Aviakosm. Ekol. Med, 2002, vol. 36, no. 4, p. 20.

    CAS  Google Scholar 

  2. Alferova, I.V., Turchaninova, V.F., Golubchikova, Z.A., et al., Diagnostic Potential of the Lower Body Negative Pressure Test within a Medical Monitoring Program in Long-Duration Space Flights, Aviakosm. Ekol. Med, 2007, vol. 41, no. 4, p. 25.

    Google Scholar 

  3. At’kov, O.Yu. and Bednenko, V.S., Gipokineziya i nevesomost’, klinicheskie i fiziologicheskie aspekty (Hypokinesia and Weightlessness: Clinical and Physiological Aspects), Moscow, 1989.

  4. At’kov, O.Yu., Bednenko, V.S., Fomina, G.A., et al., Ultrasound Investigations in Weightlessness, in Fiziologicheskie issledovaniya v nevesomosti (Physiological Investigations in Weightlessness), Simonov, P.V. and Kas’yan, I.I., Eds., Moscow, 1983, p. 49.

  5. Bardichevskii, M.Ya., Venoznaya distsirkulyatornaya patologiya golovnogo mozga (Cerebral Venous Circulation Disorders), Moscow, 1989.

  6. Voronkov, Yu.I., Kuz’min, M.P., Matsnev, E.I., et al., Results of Long-Term Monitoring of the Health of the Cosmonauts in Space Missions on board the Mir Orbital Station, in Orbital’naya stantsiya “Mir”. Kosmicheskaya biologiya i meditsina (The Mir Orbital Station: Space Biology and Medicine), Moscow, 2001, vol. 1, p. 639.

    Google Scholar 

  7. Dembo, A.G. and Zemtsovskii, E.V., Sportivnaya kardiologiya (Sports Cardiology), Leningrad, 1989.

  8. Dzizinskii, A.A., Chernyak, B.A., Kuklin, S.G., et al., Tolerance to a Physical Load and Specificities of Hemodynamic Provision in Healthy Humans Depending on the Type of Hemodynamics, Kardiologiya, 1984, no. 2, p. 68.

  9. Doroshev, V.G., Sistemnyi podkhod k zdorov’yu letnogo sostava v XXI veke (Systemic Approach to the Flight Personnel Health in the 21st Century), Moscow, 2000.

  10. Egorov, A.D., Itsekhovskii, O.G., Kas’yan, I.I., et al., Data on the Hemodynamics and Phase Structure of the Heart Cycle in Cosmonauts in Long-Duration Space Flights, in Fiziologicheskie issledovaniya v nevesomosti (Physiological Investigations in Weightlessness), Simonov, P.V. and Kas’yan, I.I., Eds., Moscow, 1983, p. 81.

  11. Egorov, A.D., Itsekhovskii, O.G., Alferova, I.V., et al., Cardiovascular Investigations in Long-Duration Space Missions, in Fiziologicheskie problemy nevesomosti, (Physiological Problems of Weightlessness), Gazenko, O.G. and Kas’yan, I.I., Eds., Moscow, 1990, p. 70.

  12. Egorov, A.D., Itsekhovskii, O.G., and Turchaninova, V.F., et al. The Functional State of the Cardiovascular System in Cosmonauts under the Conditions of Long-Duration Orbital Flights of the Salyut-6 Station, Vestn. Akad. Med. Nauk SSSR, 1964, no. 4, p. 55.

  13. Kotovskaya, A.R., Vil’-Vil’yams, I.F. Tolerance of +Gx Overload by the Cosmonauts, in Orbital’naya stantsiya “Mir”. Kosmicheskaya biologiya i meditsina (The Mir Orbital Station: Space Biology and Medicine), Moscow, 2001, vol. 1, p. 500.

    Google Scholar 

  14. Kotovskaya, A.R. and Vil’-Vil’yams, I.F., Specificities in the Physiological Reactions of Career Cosmonauts on the ISS to the Effect of +Gx Overloads in Short-Term Space Missions, Aviakosm. Ekol. Med., 2007, vol. 41, no. 3, p. 7.

    Google Scholar 

  15. Luk’yanyuk, V.Yu., Tolerance of Loads by Persons from Non-Flying Staff of Different Ages, Healthy and with Deviations of Their Health State in the Form of Initial Signs of Atherosclerosis, Extended Abstract of Cand. Sci. (Med.) Dissertation, Moscow, 1984.

  16. Sokolova, I.V., Yarullin, Kh.Kh., Maksimova, I.M., and Ronkin, M.A., Analysis of the Rheoencephalogram Structure as a Biosignal of Pulse Blood Flow, Zh. Nevropatol. Psikhiatr., 1977, vol. 77, no. 9, p. 1314.

    PubMed  CAS  Google Scholar 

  17. Turchaninova, V.F., Kas’yan, I.I., and Domracheva, M.V., Rheographic Investigations in Weightlessness, in Fiziologicheskie issledovaniya v nevesomosti (Physiological Investigations in Weightlessness), Simonov, P.V. and Kas’yan, I.I., Eds., Moscow, 1983, p. 100.

  18. Turchaninova, V.F., Domracheva, M.V., Kas’yan, I.I., et al., Specificities of the Central and Regional Blood Flow in Short-Term Space Flights, in Fiziologicheskie problemy nevesomosti, (Physiological Problems of Weightlessness), Gazenko, O.G. and Kas’yan, I.I., Eds., Moscow, 1990, p. 93.

  19. Turchaninova, V.F., Alferova, I.V., Golubchikova, Z.A., et al., Application of Lower Body Negative Pressure in Long-Duration Space Flights, in Orbital’naya stantsiya “Mir”. Kosmicheskaya biologiya i meditsina (The Mir Orbital Station: Space Biology and Medicine), Moscow, 2001, vol. 1, p. 295.

    Google Scholar 

  20. Shkhvatsabaya, I.K., Konstantinov, E.N., and Gundarev, I.A., A New Approach to the Understanding of Hemodynamic Norm, Kardiologiya, 1981, vol. 21, no. 3, p. 10.

    Google Scholar 

  21. Yarullin, Kh.Kh., Klinicheskaya reoentsefalografiya (Clinical Rheoencephalography), Moscow, 1983.

Download references

Author information

Authors and Affiliations

  1. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, 123007, Russia

    V. F. Turchaninova, I. V. Alferova & V. V. Krivolapov

Authors
  1. V. F. Turchaninova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. V. Alferova
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. V. V. Krivolapov
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Original Russian Text © V.F. Turchaninova, I.V. Alferova, V.V. Krivolapov, 2010, published in Aviakosmicheskaya i Ekologicheskaya Meditsina, 2010, Vol. 44, No. 1, pp. 20–15.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Turchaninova, V.F., Alferova, I.V. & Krivolapov, V.V. Some aspects of the comparative analysis of hemodynamic responses to LBNP tests in cosmonauts of different age groups. Hum Physiol 38, 721–726 (2012). https://doi.org/10.1134/S0362119712070249

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0362119712070249

Keywords

Search

Navigation