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Molecular markers of oxidative stress in the expired air of healthy humans

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Abstract

Chromatography-mass spectrometry of molecular metabolites in the expired air of resting healthy humans has been used to identify oxyketones, mainly 1-hydroxy-2-propanone (acetol), aldehydes (decenal, benzaldehyde), acetophenone, phenol, and fatty acids. During physical exercise (oxidative stress), the levels of ketones (heptanone-2 and heptanone-3), phenol, aldehydes identified (decenal and octadecenal), and acetol in the expired air decreased significantly, apparently, due to the prevalence of an alternative methylglycoxal metabolism of carbohydrates. It has been shown that the dynamics of saturated hydrocarbons in the expired air can be a source of information about the responses of the body to oxidative stress; while the concentration of acetone can be used as an indicator of fitness, the adequacy of physical loading, and an indicator of the development of hypoxic states.

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Authors and Affiliations

  1. Institute of Biomedical Problems, Russian Academy of Sciences, Moscow, 123007, Russia

    R. G. Mardanov, O. I. Orlov, A. A. Markin, D. S. Tsar’kov & L. N. Mukhamedieva

Authors
  1. R. G. Mardanov
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  2. O. I. Orlov
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  3. A. A. Markin
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  4. D. S. Tsar’kov
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  5. L. N. Mukhamedieva
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Additional information

Original Russian Text © R.G. Mardanov, O.I. Orlov, A.A. Markin, D.S. Tsar’kov, L.N. Mukhamedieva, 2010, published in Aviakosmicheskaya i Ekologicheskaya Meditsina, 2010, Vol. 44, No. 6, pp. 44–48.

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Mardanov, R.G., Orlov, O.I., Markin, A.A. et al. Molecular markers of oxidative stress in the expired air of healthy humans. Hum Physiol 38, 794–797 (2012). https://doi.org/10.1134/S0362119712070122

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  • DOI: https://doi.org/10.1134/S0362119712070122

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