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Features of myocardial remodeling in the most acute phase of experimental myocardial infarction

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Abstract

The features of early postischemic cardiac remodeling have been well studied both in clinical settings and in experiments. However, the data on the course of this process in the first 60 min after occlusion are scarcely available in the literature. In experiments on rats, in which acute myocardial ischemia was reproduced by one-stage ligation of the left coronary artery, echocardiography showed a sharp decline in the left ventricular systolic function during the first minutes of ischemia: after 20 min, the ejection fraction (EF) decreased from 84.5 (79.3–89.2) to 51.7 (50.2–54.4)%, p < 0.05; the shortening fraction (SF) decreased from 52.6 (47.8–59.3) to 26.5 (25.9–28.1)%, p < 0.05; and the end-systolic dimension (ESD) of the left ventricle of the heart increased from 1.90 (1.70–2.20) to 3.80 (3.50–4.10) mm, p < 0.05, whereas no statistically significant disorder of the left ventricular systolic function was observed in sham-operated animals during the observation period (60 min). A gradual relative improvement in the systolic function has been observed in the period from the 20th to the 60th minute of ischemia. After 60 min of ischemia, all the echocardiographic parameters differed significantly (p < 0.05) from those recorded after 10–20 min of the ischemic period: EF, 62.4 (59.0–64.3)%; SF, 33.7 (31.1–35.2)%; ESD, 3.10 (2.80–3.40) mm, etc. The analysis of the results suggests that the maximum reduction in the left ventricular EF observed in our experiments coincides in time with the arrhythmogenesis peak, i.e., with the maximal risk of sudden cardiac death.

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References

  1. Lichtenauer, M., Mildner, M., Baumgartner, A., et al., Intravenous and Intramyocardial Injection of Apoptotic White Blood Cell Suspensions Prevents Ventricular Remodeling by Increasing Elastin Expression in Cardiac Scar Tissue after Myocardial Infarction, Basic Res. Cardiol., 2011, vol. 106, no. 4, p. 645.

    Article  PubMed  Google Scholar 

  2. Kitabayashi, K., Siltanen, A., Patila, T., et al., Bcl-2 Expression Enhances Myoblast Sheet Transplantation Therapy for Acute Myocardial Infarction, Cell Transplant., 2010, vol. 19, no. 5, p. 573.

    Article  PubMed  Google Scholar 

  3. Herrmann, J.L., Abarbanell, A.M., Wang, Y., et al., Transforming Growth Factor-α Enhances Stem Cell-Mediated Postischemic Myocardial Protection, Ann. Thorac. Surg., 2011, vol. 92, no. 5, p. 1719.

    Article  PubMed  Google Scholar 

  4. dos Santos, L., Mello, A.F., Antonio, E.L., and Tucci, P.J., Determination of Myocardial Infarction Size in Rats by Echocardiography and Tetrazolium Staining: Correlation, Agreements, and Simplifications, Braz. J. Med. Biol. Res., 2008, vol. 41, p. 199.

    Article  PubMed  Google Scholar 

  5. Dayan, A., Feinberg, M.S., Holbova, R., et al., Swimming Exercise Training Prior to Acute Myocardial Infarction Attenuates Left Ventricular Remodeling and Improves Left Ventricular Function in Rats, Ann. Clin. Lab. Sci., 2005, vol. 35, no. 1, p. 73.

    PubMed  Google Scholar 

  6. Hagstrom, R.M., Federspiel, C.F., and Ho, Y.C., Incidence of Myocardial Infarction and Sudden Death from Coronary Heart Disease in Nashville, Tennessee, Circulation, 1971, vol. 44, p. 884.

    Article  PubMed  CAS  Google Scholar 

  7. Kuller, L.H., Cooper, M., Perper, J., and Fisher, R., Myocardial Infarction and Sudden Death in an Urban Community, Bull. N.Y. Acad. Med., 1973, vol. 49, no. 6, p. 532.

    PubMed  CAS  Google Scholar 

  8. Campbell, R.W.F., Murray, A., and Julian, D.G., Ventricular Arrhythmias in First 12 Hours of Acute Myocardial Infarction. Natural History Study, Br. Heart J., 1981, vol. 46, p. 351.

    Article  PubMed  CAS  Google Scholar 

  9. Zipes, D.P. and Wellens, H.J.J., Sudden Cardiac Death, Circulation, 1998, vol. 98, p. 2334.

    Article  PubMed  CAS  Google Scholar 

  10. Zipes, D.P., Camm, A.J., Borggrefe, M., et al., ACC/AHA/ESC 2006 Guidelines for Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death. A Report of the American College of Cardiology/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death/Developed in Collaboration with the European Heart Rhythm Association and the Heart Rhythm Society), J. Am. Coll. Cardiol., 2006, vol. 48, p. e247.

    Article  PubMed  Google Scholar 

  11. Lang, R.M., Bierig, M., Devereux, R.B., et al., Recommendations for Chamber Quantification: A Report from the American Society of Echocardiography’s Guidelines and Standards Committee and the Chamber Quantification Writing Group, Developed in Conjunction with European Association of Echocardiography, a Branch of the European Society of Cardiology, J. Am. Soc. Echocardiogr., 2005, vol. 18, p. 1440.

    Article  PubMed  Google Scholar 

  12. Martinez, P.F., Okoshi, K., Zornoff, L.A.M., et al., Echocardiographic Detection of Congestive Heart Failure in Postinfarction Rats, J. Appl. Physiol., 2011, vol. 111, p. 543.

    Article  PubMed  Google Scholar 

  13. Chang, S.-H., Liu, C.-J., Kuo, C.-H., et. al., Garlic Oil Alleviates MAPKs- and IL-6-Mediated Diabetes-Related Cardiac Hypertrophy in STZ-Induced DM Rats, Evidence-Based Complementary and Alternative Medicine, 2011, vol. 2011, ID 950150.

  14. Khong, F.L., Zhang, Y., Edgley, A.J., et al., 3,4-Dihydroxyflavonol Antioxidant Attenuates Diastolic Dysfunction and Cardiac Remodeling in Streptozotocin-Induced Diabetic m(ren2)27 Rats, PloS One, 2011, vol. 6, no. 7, p. e22777.

    Article  PubMed  CAS  Google Scholar 

  15. Rimbaud, S., Ruiz, M., Piquereau, J., et al., Resveratrol Improves Survival, Hemodynamics and Energetics in a Rat Model of Hypertension Leading to Heart Failure, PloS One, 2011, vol. 6, no. 10, p. e26391.

    Article  PubMed  CAS  Google Scholar 

  16. Sun, S., Wang, X., Qu, X., et al., Increased Expression of Myocardial Semaphorin 3A in Isoproterenol-Induced Heart Failure Rats, Clin. Med. J., 2011, vol. 124, no. 14, p. 2173.

    CAS  Google Scholar 

  17. Laboratory Rat (Reference Material), Labor. Zhivotnye, 1993, vol. 3, no. 2, p. 111.

  18. Laboratory Animal Medicine, Fox, J.G. et al., Eds., Orlando: Acad. Press, 1984.

    Google Scholar 

  19. Saridakis, N.S., Toumanidis, S.T., Vintzileou, A.M., et al., Effects of Dobutamine on Left Ventricular Functional Geometry after Acute Myocardial Infarction: Experimental Study, Hellenic J. Cardiol., 2007, vol. 48, p. 72.

    PubMed  Google Scholar 

  20. Stalioraityte, E., Bluzas, J., Mackiewicz, Z., et al., Out-of-Hospital Coronary Heart Disease Death: Acute Pathological Lesions, Acta Cardiol., 2008, vol. 63, no. 4, p. 423.

    Article  PubMed  Google Scholar 

  21. Hearse, D.J., Ferrari, R., and Sutherland, F.J., Cardioprotection: Intermittent Ventricular Fibrillation and Rapid Pacing Can Induce Preconditioning in the Blood-Perfused Rat Heart, J. Mol. Cell. Cardiol., 1999, vol. 31, no. 11, p. 1961.

    Article  PubMed  CAS  Google Scholar 

  22. Yan, G.X., Joshi, A., Guo, D., et al., Phase 2 Reentry as a Trigger to Initiate Ventricular Fibrillation during Early Acute Myocardial Ischemia, Circulation, 2004, vol. 110, no. 9, p. 1036.

    Article  PubMed  Google Scholar 

  23. Štengl, M., Experimental Models of Spontaneous Ventricular Arrhythmias and of Sudden Cardiac Death, Physiol. Res., 2010, vol. 59,suppl. 1, p. S25.

    PubMed  Google Scholar 

  24. Curtis, M.J., Characterization, Utilization and Clinical Relevance of Isolated Perfused Heart Models of Ischemia-Induced Ventricular Fibrillation, Cardiovasc. Res., 1998, vol. 39, p. 194.

    Article  PubMed  CAS  Google Scholar 

  25. Rankovic, V., Patel, N., Jain, S., et al., Characteristics of Ischemic and Periischemic Regions during Ventricular Fibrillation in the Canine Heart, J. Cardiovasc. Electrophysiol., 1999, vol. 10, no. 8, p. 1090.

    Article  PubMed  CAS  Google Scholar 

  26. Swann, M.N., Nakagawa, H., Vanoli, E., et al., Heterogeneous Regional Endocardial Repolarization Is Associated with Increased Risk for Ischemia-Dependent Ventricular Fibrillation and Myocardial Infraction, J. Cardiovasc. Electrophysiol., 2003, vol. 14, no. 8, p. 873.

    Article  PubMed  Google Scholar 

  27. Takahashi, T., van Dessel, P., Lopshire, J.C., et al., Optical Mapping of the Functional Reentrant Circuit of Ventricular Tachycardia in Acute Myocardial Infarction, Heart Rhythm, 2004, vol. 1, no. 4, p. 451.

    Article  PubMed  Google Scholar 

  28. Mehta, D., Curwin, J., Gomes, A., and Fuster, V., Sudden Death in Coronary Artery Disease. Acute Ischemia versus Myocardial Substrate, Circulation, 1997, vol. 96, p. 3215.

    Article  PubMed  CAS  Google Scholar 

  29. Luqman, N., Sung, R.J., Wang, C.L., and Kuo, C.T., Myocardial Ischemia and Ventricular Fibrillation: Pathophysiology and Clinical Implications, Int. J. Cardiol., 2007, vol. 119, no. 3, p. 283.

    Article  PubMed  Google Scholar 

  30. Crisu, D., Sudden Death and Ventricular Arrhythmias Risk Stratification after Myocardial Infarction, Rev. Med. Chir. Soc. Med. Nat. Iasi., 2010, vol. 114, no. 1, p. 13.

    PubMed  Google Scholar 

  31. Myerburg, R.J. and Junttila, M.J., Sudden Cardiac Death. Sudden Cardiac Death Caused by Coronary Heart Disease, Circulation, 2012, vol. 125, p. 1043.

    Article  PubMed  Google Scholar 

  32. Rudic, B., Veltmann, C., Kuntz, E., et al., Early Repolarization Pattern Is Associated with Ventricular Fibrillation in Patients with Acute Myocardial Infarction, Heart Rhythm, 2012, vol. 9, no. 8, p. 1295.

    Article  PubMed  Google Scholar 

  33. Bauer, A., Barthel, P., Schneider, R., et al., Improved Stratification of Autonomic Regulation for Risk Prediction in Post-Infarction Patients with Preserved Left Ventricular Function (ISAR-Risk), Eur. Heart J., 2009, vol. 30, no. 5, p. 576.

    Article  PubMed  Google Scholar 

  34. Chung, S.S., Early Identification of Risk Factors for Sudden Cardiac Death, Nat. Rev. Cardiol., 2010, vol. 7, no. 6, p. 318.

    Article  Google Scholar 

  35. El-Sherif, N., Khan, A., Savarese, J., and Turitto, G., Pathophysiology, Risk Stratification, and Management of Sudden Cardiac Death in Coronary Artery Disease, Cardiol. J., 2010, vol. 17, no. 1, p. 4.

    PubMed  Google Scholar 

  36. Santangeli, P., Dello Russo A., Caselia M., et al., Left Ventricular Ejection Fraction for the Risk Stratification of Sudden Cardiac Death: Friend or Foe? Internal Med. J., 2011, vol. 41, p. 55.

    Article  CAS  Google Scholar 

  37. Clements-Jewery, H., Hearse, D.J., and Curtis, M.J., Phase 2 Ventricular Arrhythmias in Acute Myocardial Infarction: A Neglected Target for Therapeutic Antiarrhythmic Drug Development and for Safety Pharmacology Evaluation, Br. J. Pharmacol., 2005, vol. 145, no. 5, p. 551.

    Article  PubMed  CAS  Google Scholar 

  38. Oikonomodis, D., Baltogiannis, G., and Kolettis, T.M., Do Endothelin Receptor Antagonists Have an Antiarrhythmic Potential during Acute Myocardial Infarction? Evidence from Experimental Studies, J. Interv. Card. Electrophysiol., 2010, vol. 28, p. 157.

    Article  Google Scholar 

  39. de Groot, J.R. and Coronel, R., Acute Ischemia-Induced Gap Junctional Uncoupling and Arrhythmogenesis, Cardiovasc. Res., 2004, vol. 62, p. 323.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Zakusov Research Institute of Pharmacology, Russian Academy of Sciences, Moscow, Russia

    S. A. Kryzhanovskii, E. O. Ionova, V. N. Stolyaruk, I. B. Tsorin & M. B. Vititnova

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  1. S. A. Kryzhanovskii
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  2. E. O. Ionova
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Original Russian Text © S.A. Kryzhanovskii, E.O. Ionova, V.N. Stolyaruk, I.B. Tsorin, M.B. Vititnova, 2012, published in Fiziologiya Cheloveka, 2012, Vol. 38, No. 6, pp. 43–52.

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Kryzhanovskii, S.A., Ionova, E.O., Stolyaruk, V.N. et al. Features of myocardial remodeling in the most acute phase of experimental myocardial infarction. Hum Physiol 38, 595–603 (2012). https://doi.org/10.1134/S0362119712060096

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