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Study of the indices of antioxidant defense in mental maladaptation

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Abstract

Changes in the balance of the pro- and antioxidant systems were studied in patients with mental maladaptation induced by emotional stress. We found activation of lipid peroxidation associated with accumulation of malondialdehyde in erythrocytes and blood serum of the subjects. The activity of catalase and glutathione peroxidase in erythrocytes in patients with mental stress increased, whereas the activities of glutathione reductase, glutathione-S-transferase, and glucose-6-phosphate dehydrogenase significantly decreased as compared to the group of healthy individuals. Comparative chemiluminescent analysis of the blood serum revealed a decrease in general antioxidant properties of the blood in the groups studied after mental stress.

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Authors and Affiliations

  1. Institute of Mental Health, Siberian Branch, Russian Academy of Medical Sciences, Tomsk, Russia

    L. P. Smirnova, S. A. Ivanova, N. M. Krotenko, L. A. Levchuk, E. V. Gutkevich & V. Ya. Semke

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  1. L. P. Smirnova
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  2. S. A. Ivanova
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  3. N. M. Krotenko
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  4. L. A. Levchuk
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  5. E. V. Gutkevich
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  6. V. Ya. Semke
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Original Russian Text © L.P. Smirnova, S.A. Ivanova, N.M. Krotenko, L.A. Levchuk, E.V. Gutkevich, V.Ya. Semke, 2012, published in Fiziologiya Cheloveka, 2012, Vol. 38, No. 5, pp. 108–111.

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Smirnova, L.P., Ivanova, S.A., Krotenko, N.M. et al. Study of the indices of antioxidant defense in mental maladaptation. Hum Physiol 38, 543–547 (2012). https://doi.org/10.1134/S0362119712040135

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  • DOI: https://doi.org/10.1134/S0362119712040135

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