Abstract
Electropolygraphic study of natural night sleep was performed in 16 adult subjects using correlation, coherent, cluster, and factor analyses. New evidence testifies to the active nature of sleep, which is especially manifest during falling asleep and transition from one stage of sleep to another. Falling asleep and deepening the sleep proved to be accompanied by intense reorganization of the cortico-subcortical relationships, which is reflected in the dynamics of cross-correlative and coherent interrelationships of the brain’s bioelectric potentials. Transition from wakefulness to sleep is a heterogeneous process, which is expressed in significant changes in the weights of factors I, II and III of the vector image of multichannel EEG at stage I (B) of sleep, which might reflect changes in the contribution of the main integrative brain system in the reorganization of the brain’s integrated activity. A considerable increase in the weight of factor I (this reflects generalized the modulating effect of the brainstem on the cortex) and a decrease in the weights of factors II and III (which are related to fronto-occipital and interhemispheric interactions) testify to the special synchronizing role of the brainstem in the development of this initial stage of sleep. Deeper sleep is accompanied by a decrease in interhemispheric EEG relationships of the anterior and inferior frontal areas of the cortex, which suggests that coordinated inactivation of the cortex in both hemispheres leads to reorganization of the activity in the frontal areas. Analysis of the average variance of cross-correlative (CC) EEG relationships demonstrates that stability of the spatial structure of interrelationships between various areas of the brain cortex increases with falling asleep at stage I (A); however, during transition to stage I (B), the CC EEG values become unstable and, with deepening sleep, the variance of these values decreases in the frontal brain cortex. With the onset of the paradoxical phase of sleep, the variance of the levels of interregional interactions increases to the maximum, especially with respect to the EEG relations of the posteriotemporal and inferiofrontal areas of both hemispheres.
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References
Datta, S., MacLean, R.R., Neurobiological Mechanisms for the Regulation of Mammalian Sleep-Wake Behavior: Reinterpretation of Historical Evidence and Inclusion of Contemporary Cellular and Molecular Evidence, Neurosci. Biobehav. Rev., 2007, vol. 31, p. 775.
Saper, I.B., Fuller, P.M., Pedersen, N.P., et al., Sleep State Switching, Neuron, 2010, vol. 68, no. 6, p. 1023.
Koval’zon, V.M., Osnovy somnologii: fiziologiya i neirokhimiya tsikla “bodrstvovanie-son” (Principles of Somnology: Physiology and Neurochemistry of the “Wake-Sleep” Cycle), Moscow: Binom. Laboratoriya Znanii, 2011.
Koval’zon, V.M., Central Mechanisms of the Sleep-Wakefulness Cycle Control, Hum. Physiol., 2011, vol. 37, no. 4, p. 500.
Larson-Prior, L.J., Zempel, J.M., Nolan, T.S., et al., Cortical Network Functional Connectivity in the Descent to Sleep, Proc. Natl. Acad. Sci. U.S.A., 2009, vol. 106, no. 11, p. 4489.
Tsitseroshin, M.N. and Shepoval’nikov, A.N., Stanovlenie integrativnoi funktsii mozga (Formation of the Integrative Brain Function), Bekhtereva, N.P., Ed., St. Petersburg: Nauka, 2009.
Dang-Vu, T.T., Schabus, M., Desseilles, M., et al., Functional Neuroimaging Insights Into the Physiology of Human Sleep, Sleep, 2010, vol. 33, no. 12, p. 1589.
Stickgold, R. and Walker, M.P., Sleep-Dependent Memory Consolidation and Reconsolidation, Sleep Med., 2007, vol. 8, no. 4, p. 331.
Vassalli, A. and Dijk, D-J., Sleep Function: Current Question and New Approaches, Eur. J. Neurosci., 2009, vol. 29, p. 1830.
Walker, M.P. and Stickgold, R., Overnight Alchemy: Sleep-Dependent Memory Evolution, Nat. Rev. Neurosci., 2010, vol. 11 (3), p. 218.
Diekelmann, S. and Born, J., The Memory Function of Sleep, Nat. Rev. Neurosci, 2010, vol. 11, no. 2, p. 114.
Steriade, M.M. and McCarley, R.W., Brain Control of Wakefulness and Sleep, New York: Springer, 2005.
Halasz, P., The Microstructure of the Sleep, Suppl. Clin. Neurophysiol., 2004, vol. 57, p. 521.
Rechtschaffen, A. and Kales, A., A manual of Standardized Terminology Techniques and Scoring System for Sleep Stages of Human Subjects, Washington: Public Health Service, US Government Printing Office, 1968.
Loomis, A.L., Harvey, E.N., and Hobart, G.A., Cerebral Stages During Sleep, as Studied by Human Brain Potentials, J. Exp. Psychol., 1937, vol. 21, no. 2, p. 127.
Shepoval’nikov, A.N., Tsitseroshin, M.N., Rozhkov, V.P., et al., Interregional Cortical Interaction at Different Stages of Natural Sleep and the Hypnotic State, Hum. Physiol., 2005, vol. 31, no. 2, p. 150.
Dementienko, V.V., Dorokhov, V.B., Gerus, S.V., et al., A Biomathematical Model of a Human Operator’s Falling Asleep, Hum. Physiol., 2008, vol. 34, no. 5, p. 592.
Kovrov, G.V., Posokhov, S.I., and Strygin, K.N., Interhemispheric Asymmetry (EEG data) during the Night Sleep in Patients with Insomnia, Bull. Exp. Bio. Med., 2006, vol. 141, no. 2, p. 157.
Luria, A.R., Lobnye doli i regulyatsiya psikhicheskikh protsessov (Frontal Lobes and Regulation of Psychical Processes), Moscow: Mosk. Gos. Univ., 1966.
Goldberg, E., The Executive Brain: Frontal Lobes and the Civilized Mind, (D. Bugakova translator), 2003, Moscow: Smysl.
Belenkov, N.Yu., Frontal Neocortex as the Link of the Integrated Inhibitory Brain System, Mekhanizmy integrativnoi deyatel’nosti mozga (Mechanisms of the Integrative Brain System), Moscow: Nauka, 1981, p. 143.
Tsitseroshin, M.N., Ivonin, A.A., Pogosyan, A.A., et al., The Role of the Genotype in the Development of the Neurophysiological Mechanisms Involved in the Spatial Integration of the Neocortex Bioelectric Activity, Hum. Physiol., 2003, vol. 29, no. 4, p. 393.
Shepoval’nikov, A.N., Tsitseroshin, M.N., and Apanasionok, V.S., Formirovanie biopotentsial’nogo polya mozga cheloveka (Formation of the Bioelectric potential Field of the Human Brain), Leningrad: Nauka, 1979.
Gal’perina, E.I., Kruchinina, O.V., and Tsaparina, D.M., On Age Specific of EEG Sleep Stages Transition in Children, Neuroscience for Medicine and Psychology, Abstracts of Papers, Neironauka dlya meditsiny i psikhologii: 6-i Mezhdunarodnyi mezhdistsiplinarnyi congress, (VI International Congress), Sudak, 2010, p. 322.
Kovrov, G.V. and Posokhov, S.I., Segmental Organization of Sleep, Zh. Vyssh. Nervn. Deyat., 2002, vol. 22, no. 5, p. 570.
Shepoval’nikov, A.N. and Gol’bin, A.Ts., Age-Dependent Features of the Autonomic and Motor Reactions in the Successive Sleep Cycles, in Son i trevozhnost’ (Sleep and Anxiety), Rostov-on-Don: YuFNTs RAN, 2008, p. 215.
Shepoval’nikov, A.N. and Gol’bin, A.Ts., On the Possible Role of Parasomnia as a Factor for Stabilization of Sleep Cycles, Zh. Evol. Biochem. Physiol., 2009, vol. 45, no. 6, p. 567.
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Original Russian Text © A.N. Shepovalnikov, M.N. Tsitseroshin, E.I. Galperina, V.P. Rozhkov, O.V. Kruchinina, L.G. Zaitseva, E.A. Panasevich, 2012, published in Fiziologiya Cheloveka, 2012, Vol. 38, No. 3, pp. 5–17.
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Shepovalnikov, A.N., Tsitseroshin, M.N., Galperina, E.I. et al. Characteristics of integrative brain activity during various stages of sleep and in transitional states. Hum Physiol 38, 227–237 (2012). https://doi.org/10.1134/S0362119712030127
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DOI: https://doi.org/10.1134/S0362119712030127