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Relationship between oxygen saturation of mixed venous blood and pressure in the pulmonary artery trunk in healthy humans and patients with heart defects

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Abstract

The relationship between pulmonary artery pressure (P LA) and oxygen saturation of mixed venous blood (S V ) has been studied in subjects (1750 men and 1026 women) subdivided into 12 groups. Functional relationships have been found between P LA and S V , P LA = f(S V ), and S V = f(P LA), which were estimated using direct measurement of P LA and S V for each group. These factors have been found to obey the following dependences: P LA = f(S V ) and P LA = a(S V )−b, where b = −0.2284a + 0.6564 in men and b = −0.285a + 1.2947 in women; S V = f(P LA) and S V = c(P LA)−d, where d = −0.25131Ln(c) + 1.0212; R 2 = 0.8993 in men and d = −1.9645Ln(c) + 2.852; and R 2 = 0.9674 in women. Each group occupies a position on the curves specified by the equations. Subjects with the diagnosis of a functional heart murmur and patients with congenital aortic valve stenosis were grouped together to form the so-called normal group characterized by specific P LA = f(S V ) and S V = f(P LA) dependences. Male patients with coronary heart disease were also included in the normal group. An equation was derived to relate P LA caused by different reasons with the corresponding saturation of mixed venous blood. In the case of the changing saturation of mixed venous blood, this equation gives the corresponding value of P LA. Equilibrium between systemic and pulmonary circulations is established through interdependent changes in the physiological indices of blood circulation and gas exchange in humans.

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Authors and Affiliations

  1. Meshalkin Novosobirsk State Research Institute of Circulation Pathology, Russian Agency for Medical Technologies, Novosibirsk, 630055, Russia

    Yu. A. Vlasov & A. V. Boboshko

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  1. Yu. A. Vlasov
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  2. A. V. Boboshko
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Original Russian Text © Yu.A. Vlasov, A.V. Boboshko, 2011, published in Fiziologiya Cheloveka, 2011, Vol. 37, No. 4, pp. 35–43.

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Vlasov, Y.A., Boboshko, A.V. Relationship between oxygen saturation of mixed venous blood and pressure in the pulmonary artery trunk in healthy humans and patients with heart defects. Hum Physiol 37, 422–429 (2011). https://doi.org/10.1134/S0362119711030169

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  • DOI: https://doi.org/10.1134/S0362119711030169

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