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Metabolic, ethnic, constitutional specificity of antibacterial immunity

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Abstract

Constitutional antibacterial immunity in different ethnic groups (populations) may be related to their genetically determined metabolic status—phenotypes of enzymatic reactions of metabolization (biotransformation) of xenobiotics—and expressed to different degrees depending on the frequency of the carriers of these phenotypes in populations; i.e., it may be ethnic-specific. The probability of the presence in different populations of the association of constitutional immunity to brucellosis, tuberculosis, and cholera with the oxidation and/or N-acetylation status, i.e., the ethnic dependence of the immunity, has been theoretically shown. Three variants of this dependence are presented. For revealing the ethnic dependence of constitutional immunity and predicting ethnic predisposition to bacterial infections, we need the “metabolic ethnic immunological data register” of the population. The results of such a study can be used in immunology for the assessment of the manifestation of metabolic ethnic constitutional antibacterial immunity and in epidemiology for the assessment of epidemiological situations in countries with the corresponding ethnic composition.

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Authors and Affiliations

  1. Center of Theoretical Problems of Physico-Chemical Pharmacology, Russian Academy of Sciences, Moscow, 117977, Russia

    L. A. Piruzyan & E. M. Mikhailovskii

  2. Semenov Institute of Chemical Physics, Russian Academy of Sciences, Moscow, 117977, Russia

    L. A. Piruzyan & E. M. Mikhailovskii

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  1. L. A. Piruzyan
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  2. E. M. Mikhailovskii
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Original Russian Text © L.A. Piruzyan, E.M. Mikhailovskii, 2009, published in Fiziologiya Cheloveka, 2009, Vol. 35, No. 3, pp. 108–118.

This work is based on L.A. Piruzyan’s original concept. It is published as a discussion paper.

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Piruzyan, L.A., Mikhailovskii, E.M. Metabolic, ethnic, constitutional specificity of antibacterial immunity. Hum Physiol 35, 357–368 (2009). https://doi.org/10.1134/S0362119709030128

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