Population statistical methodology for determining the mechanisms of physiological regulation of concentrations of some biochemical substances in blood

Abstract

The population statistical methodology has been considered in terms of its application to determining the physiological mechanisms providing constant concentrations in blood for different groups of biochemical substances. As applied to the group of substances with asymmetric statistical distributions, a mathematical model has been developed for breaking down such distribution into two components: normal distributions conditioned by the independent rates of substance inflow to the blood (production) and clearance, i.e., the blood volume from which all this substance is removed per time unit. The mathematical treatment of data sets (46155 subjects) made it possible to assess the parameters of this regulation at the population level. It is concluded that the mathematical treatment of biometric data based on the probability theory followed by the factual analysis of the results may be a useful tool for obtaining valuable physiological information not only on the case under study.