Human Physiology

, 34:477 | Cite as

Polymorphism of the vascular endothelial growth factor gene (VEGF) and aerobic performance in athletes

  • I. I. Ahmetov
  • A. M. Khakimullina
  • D. V. Popov
  • S. S. Missina
  • O. L. Vinogradova
  • V. A. Rogozkin


The subject of this study is the frequency distribution of alleles of the vascular endothelial growth factor gene (VEGF; the G-634C polymorphism) in athletes (n = 670) and in a control group (n = 1073) and the relationships of genotypes with aerobic performance in rowers (n = 90). Genetic typing was performed using the analysis of restriction fragment length polymorphism. The frequency of the VEGF C allele in the group of endurance athletes (n = 294) was significantly higher than in the control group and increased together with increasing sports qualification. In addition, a correlation of the VEGF C allele with a high aerobic performance of athletes (according to data on the maximal power and maximal oxygen consumption) and with a substantial contribution to the energy supply of aerobic metabolism (according to the values of maximal lactate content) has been found. It is inferred that the G-634C polymorphism of the VEGF gene is associated with physical performance of athletes and plays a key role in sports selection.


Vascular Endothelial Growth Factor Endurance Athlete Maximal Oxygen Consumption Vascular Endothelial Growth Factor Gene Aerobic Performance 
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Copyright information

© MAIK Nauka 2008

Authors and Affiliations

  • I. I. Ahmetov
    • 1
    • 2
  • A. M. Khakimullina
    • 2
  • D. V. Popov
    • 3
  • S. S. Missina
    • 3
  • O. L. Vinogradova
    • 3
  • V. A. Rogozkin
    • 2
  1. 1.All-Russian Research Institute of Physical Culture and SportsMoscowRussia
  2. 2.St. Petersburg Research Institute of Physical CultureSt. PetersburgRussia
  3. 3.Institute of Biomedical ProblemsRussian Academy of SciencesMoscowRussia

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