Abstract
Results of numerous studies show that a specific combination of biochemical parameters is formed in a trained body. The systemic inflammatory activity is supposed to be an integral factor involved in the formation of such a specific biochemical profile. The measurements of biochemical parameters of athletes’ blood and sympathovagal balance (via the assessment of the heart rate variability) performed in this study show that a decreased level of C-reactive protein is correlated with the count of red blood cells, hematocrit, levels of neutrophils and lymphocytes, total concentration of cholesterol and its concentration in low-density lipoproteins, activity of creatine phosphokinase, time of heart rate recovery from 170 to 120 beats/min (the HR170-120 index), and the LF/HF ratio (regarded as a marker of the sympathovagal balance). Hence, a decreased inflammatory activity can be involved in the regulation of some biochemical parameters and affect the sympathovagal balance of a trained body.
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References
Boyadejiev, N. and Taralov, Z., Red Blood Cell Variables in Highly Trained Pubescent Athletes: A Comparative Analysis, Br. J. Sports Med., 2000, vol. 34, p. 200.
Brun, J.F., Bouchahda, C., Chaze, D., et al., The Paradox of Hematocrit in Exercise Physiology: Which Is the “Normal” Range from an Hemorheologist’s Viewpoint? Clin. Hemorheol. Microcirc., 2000, vol. 22, no. 4, p. 287.
Letcher, R.L., Piekering, T.G., Chien, S., and Laragh, I.H., Effects of Exercise on Plasma Viscosity in Athletes and Sedentary Normal Subjects, Clin Cardiol., 1981, vol. 4, no. 4, p. 171.
Vikulov, A.D., Mel’nikov, A.A., and Bagrakova, S.V., Erythrocyte Aggregation in Athletes, Fiziol. Chel., 2003, vol. 29, no. 4, p. 76, [Hum. Physiol. (Engl. Transl.), 2003, vol. 29, no. 4, p. 357].
Tolfrey, K., Campbell, I.G., and Batterham, A.M., Exercise Training Induced Alterations in Prepubertal Children’s Lipid-Lipoprotein Profile. Med. Sci. Sprots Exerc., 1998, vol. 30, p. 1684.
Katona, P.G., McLean, M., Dighton, D.H., and Guz, A., Sympathetic and Parasympathetic Cardiac Control in Athletes and Nonathletes at Rest, J. Appl. Physiol., 1982, vol. 52, p. 1652.
Elenkov, I.J., Wilder, R.L., Chrousos, G.P., and Vizi, E.S., The Sympathetic Nerve—An Integrative Interface between Two Supersystems: The Brain and the Immune System, Pharmacol. Rev., 2000, vol. 52, p. 595.
Wellen, K.E. and Hotamisligil, G.S., Inflammation, Stress, and Diabetes, J. Clin. Invest., 2005, vol. 115, no. 5, p. 1111.
Libby, P., Ridker, P.M., and Maseri, A., Inflammation and Atherosclerosis, Circulation, 2002, vol. 105, p. 1135.
Khovidhunkit, W., Kim, M.S., Memon, R.A., et al., Effects of Infection and Inflammation on Lipids and Lipoprotein Metabolism: Mechanisms and Consequences to the Host, J. Lipid Res., 2004, vol. 45, p. 1169.
Emerson, S.J., Hemopoiesis: Development of Blood Cells, in Schiffman, F.J., Ed., Hematologic Pathophysiology, Philadelphia: Lippincott-Raven, 1998. Translated under the title Patofiziologiya krovi, Moscow: BINOM, 2000.
Abramson, J.L. and Vaccarino, V., Relationship between Physical Activity and Inflammation among Apparently Healthy Middle-Aged and Older US Adults, Arch. Intern. Med., 2002, vol. 162, p. 1286.
Pepys, M.B. and Hirschfield, G.M., C-Reactive Protein: A Critical Update, J. Clin. Invest., 2003, vol. 111, p. 1805.
Imai, K., Sato, H., Hori, M., et al., Vagally Mediated Heart Rate Recovery after Exercise Is Accelerated in Athletes but Blunted in Patients with Chronic Heart Failure, J. Am. Coll. Cardiol., 1994, vol. 24, p. 1529.
Goldberger, J., Sympathovagal Balance: How Should We Measure It? Am. J. Physiol. Heart Circ. Physiol., 1999, vol. 276, p. H1273.
Baevskii, R.M., Analysis of Heart Rate Variability in Space Medicine, Fiziol. Chel., 2002, vol. 28, no. 2, p. 70 [Hum. Physiol. (Engl. Transl.), 2002, vol. 28, no. 2, p. 202].
Eckberg, D.L., Sympathovagal Balance: A Critical Appraisal, Circulation, 1997, vol. 96, p. 3224.
Heilbronn, L.K., Noakes, M., and Clifton, P.M., Energy Restriction and Weight Loss on Very-Low-Fat Diets Reduce C-Reactive Protein Concentrations in Obese, Healthy Women, Arterioscler. Thromb. Vasc. Biol., 2001, vol. 21, p. 968.
Bastard, J.P., Jardel, C., Bruckert, E., et al., Elevated Levels of Interleukin-6 Are Reduced in Serum and Subcutaneous Adipose Tissue of Obese Women after Weight Loss, J. Clin. Endocrinol. Metab., 2000, vol. 85, p. 3338.
Okita, K., Nishijima, H., Murakami, T., et al., Can Exercise Training with Weight Loss Lower Serum C-Reactive Protein Levels? Arterioscler. Thromb. Vasc. Biol., 2004, vol. 24, p. 1868.
Petersen, A.M. and Pedersen, B.K., The Antiinflammatory Effect of Exercise, J. Appl. Physiol., 2005, vol. 98, p. 1154.
Semple, S.J., Smith, L.L., and McKune, A.J., Serum Concentrations of C Reactive Protein, α1 Antitrypsin, and Complement (C3, C4, C1 Esterase Inhibitor) before and during the Vuelta a Espańa, Br. J. Sports Med., 2006, vol. 40, p. 124.
Zaldivar, F., Wang-Rodriguez, J., Nemet, D., et al., Constitutive Pro-and Antiinflammatory Cytokine and Growth Factor Response to Exercise in Leukocytes, J. Appl. Physiol., 2006, vol. 100, p. 1124.
Tulppo, M.P., Hautala, A.J., and Mäkikallio, T.H., Effects of Aerobic Training on Heart Rate Dynamics in Sedentary Subjects, J. Appl. Physiol., 2003, vol. 95, p. 364.
Belova, E.L., Individual Typological Features of Psychophysiological Adaptation in Athletes, Extended Abstract of Cand. Sci. (Biol.) Dissertation, Yaroslavl, 2005.
Watanabe, Y., Takanashi, A., and Shimazu, T., Neural Control of Biosynthesis and Secretion of Serum Transferrin in Perfused Rat Liver, Biochem, J., 1990, vol. 267, p. 545.
Yu, H.-J., Lin, B.-R., Lee, H.-S., et al., Sympathetic Vesicovascular Reflex Induced by Acute Urinary Retention Evokes Proinflammatory and Proapoptotic Injury in Rat Liver, Am. J. P. Renal Physiol., 2005, vol. 288, p. F1005.
Convertino, V.A. Blood Volume: Its Adaptation to Endurance Training, Med. Sci. Sports Exerc., 1991, vol. 23, p. 1338.
Eisenmann, J.C., Womack, C.J., and Reeves, M.J., Blood Lipids in Young Distance Runners, Med. Sci. Sports Exerc., 2001, vol. 33, p. 661.
Nijm, J., Wikby, A., and Tompa, A., Circulating Levels of Proinflammatory Cytokines and Neutrophil-Platelet Aggregates in Patients with Coronary Artery Disease, Am. J. Cardiol., 2005, vol. 95, p. 452.
Steensberg, A., Toft, A.D., and Brunnsgaard, H., Strenuous Exercise Decreases the Percentage of Type 1 T Cells in the Circulation, J. Appl. Physiol., 2001, vol. 91, p. 1708.
Pedersen, B.K. and Hoffman-Goettz, L., Exercise and the Immune System: Regulation, Integration, and Adaptation, Physiol. Rev., 2000, vol. 80, no. 3, p. 1055.
Makarova, G.A. and Loktev, S.A., Kartina krovi i funktsional’noe sostoyanie organisma sportsmenov (Blood Pattern and the Functional State of Athletes), Krasnodar, 1990.
Garkavi, L.Kh., Kvakina, E.B., and Ukolova, M.A., Adaptatsionnye reaktsii i resistentnost’ organisma (Adaptive Reactions and the Resistance of the Body), Rostov-on-Don, 1977.
Sutton, D. and Schmid-Schonbein, G., Evaluation of Microvascular Perfusion: The Contribution of Different Blood Cells, in Leukocytes and Endothelial Interactions, Barcelona: Prous Science, 1995, p. 31.
Mackinnon, L., Overtraining Effects on Immunity and Performance in Athletes, Immunol. Cell Biol., 2000, vol. 78, p. 502.
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Original Russian Text © A.A. Mel’nikov, A.A. Kylosov, A.D. Vikulov, 2007, published in Fiziologiya Cheloveka, 2007, Vol. 33, No. 5, pp. 124–132.
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Mel’nikov, A.A., Kylosov, A.A. & Vikulov, A.D. Relationships of inflammatory activity with biochemical parameters of the blood and sympathovagal balance of young athletes. Hum Physiol 33, 624–631 (2007). https://doi.org/10.1134/S0362119707050143
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DOI: https://doi.org/10.1134/S0362119707050143