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The effects of leptin on the microbicidal activity of monocytes in humans

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Abstract

The effects of leptin at doses typical of the first and second to third trimesters of pregnancy on the microbicidal activity of monocytes in women were studied. It was found that the hormone modulated the enzymatic activity of neutral proteinases produced by monocytes in different ways: it stimulated the activity of elastase and inhibited the activity of cathepsin G. The study of regulation by leptin of the oxidative potential of monocytes showed that leptin in the investigated doses stimulated the enzymatic activity of myeloperoxidase and did not affect the spontaneous luminol-dependent chemiluminescence of monocytes, whereas the hormone exerted a dose-dependent activating effect on the zymosan-induced production of active oxygen metabolites by monocytes.

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Authors and Affiliations

  1. Institute of Ecology and Genetics of Microorganisms, Ural Division, Russian Academy of Sciences, Perm, 614000, Russia

    E. G. Orlova & S. V. Shirshev

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  1. E. G. Orlova
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  2. S. V. Shirshev
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Original Russian Text © E.G. Orlova, S.V. Shirshev, 2007, published in Fiziologiya Cheloveka, 2007, Vol. 33, No. 4, pp. 109–113.

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Orlova, E.G., Shirshev, S.V. The effects of leptin on the microbicidal activity of monocytes in humans. Hum Physiol 33, 481–484 (2007). https://doi.org/10.1134/S0362119707040159

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