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The role of heat shock proteins in the formation of conflict between the human body and its microflora

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Abstract

The incidence of endogenous infectious inflammatory diseases has dramatically increased in the population during the past 50 years. The causative agents of these diseases are representatives of the body’s commensal microflora, to which oral tolerance (OT) of the host develops. Disorders of this tolerance promote the development of various infections. The OT can fail as a result of stress factors acting on microorganisms, first of all, unreasonably wide use of antibacterial drugs. On the basis of the results of this study and literature data, it is shown that the abolishment of the body’s tolerance to its commensal microflora and the development of endogenous inflammations, which, in turn, induce allergic, autoimmune, and systemic diseases, are caused by a multiple increase in the level of heat shock proteins on the surface of microorganisms under the influence of stress. The pathogeneses of endogenous inflammatory diseases and therapeutic approaches are discussed.

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Authors and Affiliations

  1. Moscow State Medical Stomatological University, Moscow, 199034, Russia

    K. A. Lebedev & I. D. Ponyakina

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  1. K. A. Lebedev
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  2. I. D. Ponyakina
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Original Russian Text © K.A. Lebedev, I.D. Ponyakina, 2007, published in Fiziologiya Cheloveka, 2007, Vol. 33, No. 3, pp. 100–107.

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Lebedev, K.A., Ponyakina, I.D. The role of heat shock proteins in the formation of conflict between the human body and its microflora. Hum Physiol 33, 342–348 (2007). https://doi.org/10.1134/S0362119707030115

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  • DOI: https://doi.org/10.1134/S0362119707030115

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