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Human placental myeloperoxidase in miscarriage

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Abstract

The activity of myeloperoxidase (MPO) was studied in chorionic and placental tissues of women with miscarriage. The MPO level reached the maximum during the first trimester both in normal pregnancy and in the case of spontaneous abortion. During gestation, the MPO level decreased in the placental tissues independently of the enzyme location. The MPO levels in the placenta during the first and second trimesters were higher in the case of spontaneous abortion than in an uncomplicated pregnancy. In the third trimester, the MPO level in the placenta was significantly lower in the case of miscarriage than in normal pregnancy ending with childbirth at term. The results suggest a close correlation between the MPO level in the placenta and the possible pregnancy outcome.

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Authors and Affiliations

  1. Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St. Petersburg, 199034, Russia

    V. M. Prokopenko

  2. Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg, 197376, Russia

    G. M. Aleshina

Authors
  1. V. M. Prokopenko
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  2. G. M. Aleshina
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Original Russian Text © V.M. Prokopenko, G.M. Aleshina, 2006, published in Fiziologiya Cheloveka, 2006, Vol. 32, No. 4, pp. 131–133.

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Prokopenko, V.M., Aleshina, G.M. Human placental myeloperoxidase in miscarriage. Hum Physiol 32, 486–488 (2006). https://doi.org/10.1134/S0362119706040177

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  • DOI: https://doi.org/10.1134/S0362119706040177

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