Skip to main content
SpringerLink
Log in

Platelet aggregability in apparently healthy humans of different ages

  • Published:
Human Physiology Aims and scope Submit manuscript

Abstract

Platelet aggregability was studied in 154 apparently healthy subjects aged 18–60 years. Both spontaneous platelet aggregation and aggregation induced by inducers with different mechanisms of action were studied. In 25-to 27-year-old subjects, the parameters of both the spontaneous aggregation, which characterized the platelet activation, and ADP-induced platelet aggregation, which characterized the total platelet aggregability, were lower than in older subjects (45–50 and 60–70 years of age). The parameters of the platelet activity and aggregation indicated the absence of age-related changes in the structure and functions of platelets in response to inducers, including epinephrine, collagen, and ristocetin.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Vashkinel’, V. K. and Petrov, M. N., Ul’trastruktura i funktsiya trombotsita (The Platelet Ultrastructure and Function), Leningrad: Nauka, 1982.

    Google Scholar 

  2. Barkagan, Z. S., Gemorragicheskie zabolevaniya i sindromy (Hemorrhagic Diseases and Syndromes), Moscow: Meditsina, 1988.

    Google Scholar 

  3. Kirichuk, V. F., Fiziologiya krovi (Blood Physiology), Saratov: SarGMU, 2002.

    Google Scholar 

  4. Schneider, D. J., Taatjes, D. J., Howard, D. B., and Sobel, B. E., Increased Reactivity of Platelets Induced by Fibrinogen Independent of Its Binding to the IIb/IIIA Surface Glycoprotein: a Potential Contributor to Cardiovascular Risk, J. Am. Coll. Cardiol., 1999, vol. 33, no. 1, p. 261.

    Article  PubMed  CAS  Google Scholar 

  5. Mazurov, A. V. and Vasil’ev, S. A., Structure and Functions of Membrane Glycoproteins of Platelets, Gematol. Transfuziol., 1994, vol. 39, no. 1, p. 29.

    PubMed  CAS  Google Scholar 

  6. Kotite, N. J. and Cunningham, L. W., Specific Absorption of a Platelet Membrane Glycoprotein by Human Insoluble Collagen, J. Biol. Chem., 1986, vol. 261, p. 1355.

    Google Scholar 

  7. Nachman, R. L., Leung, L. L. K., and Polley, M. J., Molecular Mechanisms of Platelet Adhesion and Platelet Aggregation, Blood, 1986, vol. 67, p. 450.

    Google Scholar 

  8. Gabbasov, Z. A., Popov, E. G., Gavrilov, I. Yu., et al., A New Highly Sensitive Method of Platelet Aggregation Analysis, Lab. Delo, 1989, no. 10, p. 15.

  9. Gritsyuk, O. I., Amosova, K. M., and Gritsyuk, I. O., Prakticheskaya gemostaziologiya (Practical Hemostasiology), Kiev: Zdorov’ya, 1994.

    Google Scholar 

  10. Vinogradov, D. V., Vlasik, T. N., Agafonova, T. G., et al., Inhibition of the Fc-Receptor-Dependent Platelet Aggregation by Monoclonal Antibodies to the Glycoprotein Complex IIb/IIIa, Biokhimiya, 1991, vol. 56, no. 5, p. 787.

    CAS  Google Scholar 

  11. Byshevskii, A. Sh., Galyan, S. L., Dement’eva, I. A., et al., Trombotsity (Blood Platelets), Tyumen, 1996.

  12. Kirichuk, V. F., Svistunov, A. A., and Glybochko, P. V., Mekhanizmy sosudisto-trombotsitarnogo zvena sistemy gemostaza: kliniko-fiziologicheskie aspekty (Mechanisms of the Vascular-Platelet Link of the Hemostasis System: Clinical Physiological Aspects), Saratov: SGU, 1998.

    Google Scholar 

  13. Owen, N. E., Feinberg, H., and Le Breton, G. C., Epinephrine Induces Ca2+ Uptake in Human Blood Platelets, Am. J. Physiol., 1980, vol. 239, no. 4, p. 11483.

    Google Scholar 

  14. Kirchhofer, D., Languino, L. R., Ruoslahti, E., and Pierschbacher, M. D., p2al Integrins from Dill Cell Types Show Different Binding Specificities, J. Biol. Chem., 1990, vol. 256, p. 615.

    Google Scholar 

  15. Alekseeva, E. A. and Golikov, P. P., Platelet Adrenoreceptors, Gematol. Transfuziol., 1989, no. 2, p. 49.

Download references

Author information

Authors and Affiliations

  1. Saratov State Medical University, Saratov, Russia

    V. F. Kirichuk & I. V. Voskoboi

Authors
  1. V. F. Kirichuk
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. I. V. Voskoboi
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Original Russian Text © V.F. Kirichuk, I.V. Voskoboi, 2006, published in Fiziologiya Cheloveka, 2006, Vol. 32, No. 4, pp. 116–120.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kirichuk, V.F., Voskoboi, I.V. Platelet aggregability in apparently healthy humans of different ages. Hum Physiol 32, 473–477 (2006). https://doi.org/10.1134/S0362119706040153

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0362119706040153

Keywords

Search

Navigation