Skip to main content
SpringerLink
Log in

Response of the afferent vagal fibers to lipopolysaccharides of gram-negative bacteria administered intrapulmonarily: An experimental model

  • Published:
Human Physiology Aims and scope Submit manuscript

Abstract

Responses of the cervical afferent vagal fibers were studied in rats subjected to subdiaphragmatic vagotomy and administered intrapulmonarily with endotoxins of gram-negative bacteria. It was shown that 50-μg doses of lipopolysaccharides (LPSs) instilled into the rat lungs affected the activity of sensitive vagal fibers. The LPSs of Pseudomonas aeruginosa or Klebsiella pneumoniae produced a long-lasting increase in the frequency of afferent impulses, whereas the LPSs from Escherichia coli decreased it during the entire 100-min period of observation. Apyrogenic saline solution administered in control tests produced no considerable changes in the tonic activity of sensitive fibers. The endotoxins increased the respiratory rate and decreased the heart rate. The results experimentally support the idea that some components of the cell walls of gram-negative bacteria can affect both the activity of the afferent bronchopulmonary vagal fibers and intersystem interactions in the body.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Yakovlev, M.Yu., Elements of the Endotoxin Theory in Human Physiology and Pathology, Fiziol. Chel., 2003, vol. 29, no. 4, p. 98.

    Google Scholar 

  2. Gurin, V.N. and Gurin, A.V., Termoregulyatsiya i biologicheski aktivnye veshchestva krovi (Thermoregulation and Biologically Active Substances of the Blood), Minsk: Biznesofset, 2004.

    Google Scholar 

  3. Kaganov, S.Yu., The Problem of the Environment-Related Pulmonary Diseases in Children, Ross. Vestn. Perinatol. Pediat., 1996, no. 4, p. 9.

  4. Zeldin, D., Wohlford-Lenane, C., Chulada, P., et al., Airway Inflammation and Responsiveness in Prostaglandin H Synthase-Deficient Mice Exposed to Bacterial Lipopolysaccharide, Am. J. Respir. Cell Mol. Biol., 2001, vol. 25, no. 3, p. 457.

    CAS  PubMed  Google Scholar 

  5. Schwartz, D., Inhaled Endotoxin, a Risk for Airway Disease in Some People, Respir. Physiol., 2001, vol. 128, p. 47.

    Article  CAS  PubMed  Google Scholar 

  6. Vernooy, J., Dentener, M., Buurman, W., et al., Intratracheal Instillation of LPS in Mice Induces Apoptosis in Bronchial Epithelial Cells, Am. J. Respir. Cell Mol. Biol., 2001, vol. 24, p. 569.

    CAS  PubMed  Google Scholar 

  7. Neff Lecture, T., Strieter, R., Kunkel, S., et al., Chemokines in Lung Injury, Chest, 1999, vol. 116, p. 103S.

    Google Scholar 

  8. Parsey, M., Tuder, R., and Abraham, E., Neutrophils Are Major Contributors to Intraparenchymal Lung IL-1β Expression after Hemorrhage and Endotoxemia, J. Immunol., 1998, vol. 160, p. 1007.

    CAS  PubMed  Google Scholar 

  9. Shelhamer, J., Levine, S., Wu, T., et al., Airway Inflammation, NIH Conf., 1995, vol. 123, p. 288.

    CAS  Google Scholar 

  10. Gurin, A.V., Ingibitory proteinaz i tsitokiny krovi v mekhanizmakh gipertermii pri stresse (Inhibitors of Proteinases and Blood Cytokines in the Mechanisms of Hyperthermia in Stress), Minsk: Tekhnoprint, 2003.

    Google Scholar 

  11. Lu-Yuan, L. and Widdicombe, J., Modulation of Airway Sensitivity to Inhaled Irritants: Role of Inflammatory Mediators, Environ. Health Perspect. Suppl., 2001, vol. 109, p. 585.

    Google Scholar 

  12. Barnes, P.J., Neurogenic Inflammation in the Airways, Respir. Physiol., 2001, vol. 125, p. 145.

    Article  CAS  PubMed  Google Scholar 

  13. Soltanov, V.V., Morozova, I.L., and Rudaya, A.Yu., Effects of Lipopolysaccharide of Escherichia coli on the Activity of the Afferent Subdiaphragmatic Vagal Fibers, Vestsi NAN Belarusi, Ser. Med.-Biyal. Navuk, 2002, no. 2, p. 16.

  14. Soltanov V.V. and Burko, V.E., Computer Programs for Electrophysiology, Novosti Med.-Biol. Nauk, 2005, no. 1, p. 47.

  15. Kler, K., Schmidt, K., Meisik, A., and Brain, D., Bacterial Toxin, KMAX, 2000, vol. 2, no. 1, p. 19.

    Google Scholar 

  16. Korovkin, V.S., Specific Etiological and Clinical Features of the Present-Day Forms of Pneumonia, Zdravookhranenie, 2003, no. 3, p. 24.

  17. Widdicombe, J. and Lu-Yuan, L., Airway Reflexes, Autonomic Function, and Cardiovascular Responses, Environ. Health Perspect., 2001, vol. 109, p. 579.

    CAS  PubMed  Google Scholar 

  18. Deleuze, V., Lefort, J., Scherman, D., et al., LPS-Induced Bronchial Hyperreactivity: Interference by mIL-10 Differs According to Site of Delivery, Am. J. Physiol. Lung Cell Mol. Physiol., 2004, vol. 286, p. 98.

    Google Scholar 

  19. Dantzer, R., Konsman, P., Bluthe, R.-M., et al., Neural and Humoral Pathways of Communication from the Immune System to the Brain: Parallel or Convergent? Autonom. Neurosci., 2000, vol. 85, p. 60.

    CAS  Google Scholar 

  20. Soltanov, V.V., Chumak, A.G., and Rudaya, A.Yu., Changes in the Afferent Activity of Superior Mesenteric Nerves Induced by Application of Lipopolysaccharide from Escherichia coli into Small Intestinal Lumen, in Basic and Applied Thermophysiology, Gurin, V.N., Ed., Minsk, 2000, p. 103.

Download references

Author information

Authors and Affiliations

  1. Institute of Physiology, National Academy of Sciences of Belarus, Minsk, Belarus

    S. I. Lapikov, V. N. Gurin & A. V. Gurin

Authors
  1. S. I. Lapikov
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. N. Gurin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. A. V. Gurin
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Original Russian Text © S.I. Lapikov, V.N. Gurin, A.V. Gurin, 2006, published in Fiziologiya Cheloveka, 2006, Vol. 32, No. 1, pp. 108–114.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lapikov, S.I., Gurin, V.N. & Gurin, A.V. Response of the afferent vagal fibers to lipopolysaccharides of gram-negative bacteria administered intrapulmonarily: An experimental model. Hum Physiol 32, 94–99 (2006). https://doi.org/10.1134/S0362119706010142

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0362119706010142

Keywords

Search

Navigation