Due to the saturation of natural waters with nitrogen compounds resulting from natural processes and anthropogenic activities, the problem arises of studying the ways of their migration, transformation in the hydrosphere and in aquatic biota. One of the ways of nitrogen transformation in the environment is the formation of nitrosamines—toxic organisms or biota that exhibit carcinogenic, mutagenic and teratogenic properties and have a toxic effect on living beings. The main sources of nitrogen-containing compounds, precursors of nitrosamines, into waterbodies are agricultural, industrial and municipal wastewater. The present paper analyses the ways of synthesis of nitrosamines in the aquatic environment and in living organisms or biota, the main methods of analysis of these compounds, their distribution and transformation in hydrosphere, as well as the ways of decrease in their concentrations and modern techniques for removal of nitrosamines from aquatic ecosystems.
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Bandman, A.L., Volkova, N.V., Grekhova, T.D., and Gudzovskii, G.A., Vrednye khimicheskie veshchestva. Neorganicheskie soedineniya elementov V–VIII grupp: Spravochnoe izdanie (Harmful Chemical Substances. Inorganic Compounds of Elements of V–VIII Groups: Reference Book), Filov, V.A., Ed., Leningrad: Khimiya, 1989.
Val’ter, A.I., Kasatkina, O.A., and Petrenko, A.E., On the method for the analysis of nitrosamines in food products, Gig. Sanit., 1996, no. 6, pp. 49–50.
Voronin, V.M., Litvinov, N.N., Kazachkov, V.I., Shamarin, A.A., and Zhurkov, V.S., Study on the dependence of carcinogenic effect on the cancerogenecity effect on N-nitrosodiethylamine concentration, Vopr. Onkol.,1989, vol. 35, no. 6, pp. 685–689.
Gichev, Yu.P., Zagryaznenie okruzhayushchei sredy i zdorov’e cheloveka (Environmental Pollution and Human Health), Moscow. 230 p.
Dmitrienko, N.P., Kishko, O., and Shandarenko, S.G., On the rle of xantin oxidase in cytotoxic effects of nitrates and nitrites, Ukr. Biokhim. Zh., 2001, vol. 73, no. 6, pp. 113–117.
Drabkina, V.G., Causes and ways of degradation of waterbodies, in Teoriya i praktika vosstanovleniya vnutrennikh vodoemov (Theory and Practice of Restoration of Inland Waterbodies), St. Petersburg: Lema, 2007, pp. 113–120.
Zul’figarov, O.S. and Yurchenko, V.V., Carcinogenic N-nitrosamines, toxic properties, formation, determination, Sovremennye Problemy toksikologii, 2005, no. 1, pp. 53–57.
Izmailova, A.V., Foreign experience of restoration of inland waters (on the basis of materials of digital database “Earth Lakes,” in Teoriya i praktika vosstanovleniya vnutrennikh vodoemov (Theory and Practice of Restoration of Inland Waterbodies), St. Petersburg: Lema, 2007, pp. 15–162.
Il’nitskii, A.P., Yurchenko, V.A., Zhukova, G.F., and Ermilov, V.B., Assessment of extent of hazard of low doses of nitrites, Vopr. Onkol.,1989, vol. 36, no. 7, pp. 843–847.
Klochenko, P.D., Mikhailenko, V.M., and Shevchenko, T.F., Influence of nitrosamines on development of phytoplankton, Gidrobiol. Zh., 2001, vol. 37, no. 4, pp. 30–38.
Klochenko, P.D., Sakevich, A.I., Usenko, O.M., and Shevchenko, T.F., Change in structure of phytoplankton under effect of urea, Gidrobiol. Zhur., 2000, vol. 36, no. 6, pp. 62–74.
Kostyukovskii, Ya.L. and Melamed, D.B., Carcinogenic N-nitrosamines, formation, properties, analysis, Usp. Khim., 1988, vol. 57, no. 4, pp. 625–655.
Metodicheskie ukazaniya po metodam kontrolya: Metodicheskie ukazaniya, UK 4.4.1.011-93 Opredelenie letuchikh N-nitrozaminov v prodovol’stvennom syr’e i pishchevykh produktakh 1993 (Guidelines for Control Methods: Guidelines, UK 4.4.1.011–93 Determination of Volatile N-nitrosamines in Food Raw Materials and Food Products), 1993.
Moiseenko, T.I., Evolution of biogeochemical cycles in modern conditions of anthropogenic loads: exposure limits, Geokhimiya, 2017, no. 10, pp. 1–22.
Moiseenko, T.I. and Rudneva, I.I., Global pollution and functions of nitrogen in the hydrosphere, Dokl. Akad. Nauk, 2008, vol. 420, no. 3, pp. 395–400.
Nitraty, nitrity i N-nitrozosoedineniya. Gigienicheskie kriterii sostoyaniya okruzhayushchei sredy (Nitrates, Nitrites and N-nitroso Compounds. Hygienic Criteria for the State of the Environment), Geneva: WHO, 1981, p. 118.
Omel’chenko, S.O., Seasonal dynamics of nitrosamine content in some species of the Black Sea fish, Agroekologicheskii Zhurn, 2006, no. 1, pp. 72–75.
Omel’chenko, S.O., Ecotoxicological assessment of some species of the Black Sea fish, Uch. Zap. Tavricheskogo nats. un-ta, Ser. Biologiya. 2012. v. 25. No. 4, pp. 144–149
Rubenchik, B.L., Obrazovanie kantserogenov iz soedinenii azota (Formation of Carcinogens from Nitrogen Compounds), Kiev: Nauk. dumka, 1990.
Rudneva, I.I., Mel’nikova, E.B., Kuz’minova, N.S., Omel’chenko, S.O., Zalevskaya, I.N., and Simchuk, G.V., Assessment of the impact of mineral nitrogen compounds on bottom fish in the Black Sea bays, Vodn. Resur., 2008, vol. 35, no. 4, pp. 260–267.
Sal'nikova, L.S., Nitrozaminy (Nitrosamines), Moscow: Tsentr mezhdunarodnykh proektov GKNT, 1983.
Stankevich, S.V., Maktaz, E.D., and Kul’bich, T.S., Content of N-nitrosamines in waterbodies in relation to anthropogenic eutrophication, in Gigiena Naselennykh mest (Hygiene of Populated Areas), 1988, pp. 26–31.
Terekhova, V.A., Rudneva, I.I., Poromov, A.A., Paramonova, A.I., and Kydralieva, K.A., Distribution and biological effects of antibiotics in aquatic ecosystems (review), Voda: Khimiya i ekologiya, 2019, nos. 3−6, pp. 92–112.
Tutel’yan, V.A. and Luneva, N.V., On the mechanism of acute toxic action of N-nitrosodimethylamine, Farmakol. Toksikol., 1983, no. 9, pp. 111–114.
Khudolei, V.V., The role of age in carcinogenesis induced by N-nitrosodimethylamine and N-dimethylnitramine in amphibians, Vopr. Onkol., 1981, vol. 27, no. 10, pp. 67–71.
Khudolei, V.V., Malavei, V.K., and Barch, Kh., Study of mutagenic properties of carcinogenic N-nitrosamines in vivo and in vitro. Vopr. onkologii, 1981, vol. 27, no. 7, pp. 843–847.
Ekotoksikologicheskie issledovaniya pribrezhnoi chernomorskoi ikhtiofauny v raione Sevastopolya (Ecotoxicological Studies of the Coastal Black Sea Fish Fauna in the Area of Sevastopol) Rudneva, I.I., Ed., Moscow: Izd-vo GEOS, 2016.
Abidi, S.L., Dawson, V.K., and Hubley, R.C., Potential for nitrosamine formation in seven fishery chemicals, The progressive Fish-Culturist, 1986, no. 48, pp. 302–302.
Amelin, V.G. and Bol’shakov, D.S., Rapid identification and determination of n-nitrosamines in food products by ultra-high-performance liquid chromatography-high molecules, J. Analytical Chem, 2019, vol. 74, pp. 39–46.
Antia, N.J., Harrison, P.J., Oliveira, L., Anita, N.J., Harrison, P.J., and Oliveira, L., The role of dissolved organic nitrogen in phytoplankton nutrition, cell biology and ecology, Phycologia, 1991, vol. 30, pp. 1–89.
Bamba, D. and Robert, D., Nitrogen-containing organic compounds: origins, toxicity and conditions of their photocatalytic mineralization over TiO2. Total, Environ., 2, vol. 580, pp. 1489–1504.
Bartsch, H., Camus, A., and Malaveille, C., Comparative mutagenicity of N-nitrosamines in a semisolid and a liquid incubation system in the presence of rat or human tissue fractions, mutation research, Fundamental and Molecular Mechanisms of Mutagenesis, 1976, vol. 37, no. 2, pp. 149–162.
Berman, T. and Chava, S., Algal growth on organic compounds as nitrogen sources, J. Plankton Res., 1999, vol. 21, pp. 1423–1437.
Bieniarz K., Epler P., Kime D., Sokolowska-Mikolajczyk M., W. Popek W., and Mikolajczyk T., Effects of N,N-dimethylnitrosamine (dmna) on in vitro oocyte maturation and embryonic development of fertilized eggs of carp (Cyprinus carpio l.) kept in eutrophied ponds, J. Appl. Toxicol, 1996, vol. 16, pp. 153–156.
Boroumand, Y. and Razmjou, A., Mussel inspired bacteriall denitrification of water using fractal patterns of polydopamine, J. Water Process Engineering, 2020, vol. 33, pp. 101–105.
Deane, E.E. and Woo, N.Y., Impact of nitrite exposure on endocrine, osmoregulatory and cytoprotective functions in the marine teleost, Sparus sarba, 2007, vol. 32, pp. 85–93.
Fong, Y.Y., Methods for limiting the content of dimethylnitrosamine in the chinese marine salt fish, Food Cosmet. Toxicol. Biochem. Pathol (Hong Kong), 1976, vol. 14, pp. 95–98.
Gebus-Czupyt, B., Chmiel, S., Trembaczowski, A., Pelc, A., and Halas, S., Simultaneous preparation of N2 and CO2 from water nitrates for δ15N and δ18O analysis on the example of the Zemborzycki Reservoir studies, Chemosphere, 2020, vol. 248, pp. 125–154.
Gomathi Devi L., Girish Kumar S., Mohan Reddy K., Munikrishnappa C. Photo degradation of methyl orange an azo dye by advanced Fenton process using zero valent metallic iron: influence of various reaction parameters and its degradation mechanism, J. Hazard. Mater., 2009. vol. 164, nos. 2–3, pp. 45–467.
Holst, J., Brackin, R., and Robinson, N., Soluble inorganic and organic nitrogen in two australian soils under sugarcane cultivation, Agric. Ecosyst. Environ, 2012, vol. 155, pp. 16–26.
Hsieh, M.-Ch., Wei-Po, W., and Lai, L.A., Yu-Chen Lin, Sunlight photolysis mitigates the formation of N-nitrosodimethylamine (NDMA) during the chloramination of methadone, Chem. Engineer. J., 2020, vol. 384, p. 123307.
Hu, L., Yu, J., Hongmei, Luo, H., Wang, H., Xu, P., and Zhang, Y., Simultaneous recovery of ammonium, potassium and magnesium from produced water by struvite precipitation, Chem. Engineer. J., 2020, vol. 382, p. 123001.
Jensen, F.B., Nitrite disrupts multiple physiological functions in aquatic animals, Comp. Biochem. Physiol. Pt A: Mol. Integr. Physiol., 2003. vol. 135, no. 1, pp. 9–24.
Kim, O.K., Park, Y.B., Lee, T.G., Kim, I.S., Kang, J.H., Jun, K.S., Park, D.Ch., and Kim, S.B., Degradation of nitrate as a nitrosamine precursor by brown algae Ecklonia cava, J. Korean Fish, 1996, vol. 29, no. 6, pp. 914–916.
Liu H., Chen Z., Guan Y., Xu S. Role and application of iron in water treatment for nitrogen removal: a review, Chemosphere, 2018, vol. 204, pp. 51–62.
Mollamohammada, S., Hassan, A.A., and Dahab, M., Nitrate removal from groundwater using immobilized heterotrophic algae, Water, Air, & Soil Pollution, 2020, vol. 231.
Mulder, A., The quest for sustainable nitrogen removal technologies, Water Sci. Technol, 2003, vol. 48, no. 1, pp. 67–75.
Naing, N.N., Sze, Chieh Tan S.Ch., and Lee, H.K., 16—Micro-Solid-Phase Extraction. Handbooks in separation science, Amsterdam: Elsevier Inc., 2020.
Nowlin, W.H., Evarts, J.L., and Vanni, M.J., Release rates and potential fates of nitrogen and phosphorus from sediments in a eutrophic reservoir, Freshw. Biol, 2010, vol. 50, pp. 301–322.
Pedemonte, D.C., Frison, N., Taya, C., Ponsa, S., and Fatone, F., Chemical and biological processes for nutrients removal and recovery, Waste Management: Concepts, Methodologies, Tools, and Applications. Hershey, Pennsylvania: IGI Global USA, 2020, pp. 37–48.
Priya, E.R., Ravichandrana, S., Gobinatha, Th., Tilvib, S., and Devib, P.S., Functional characterization of anti-cancer sphingolipids from the marine crab Dromia dehanni, Chem. Phys. Lipids, 2019, vol. 221, pp. 73–82.
Qiu, Y., Bei, E., Wang, Y., Wang, J., Zhang, X., and Chen, Ch., One representative water supply system in China with nitrosamine concern: challenges and treatment strategies, J. Environ. Sci, 2020, vol. 88, pp. 12–20.
Rudneva, I.I., Kuzminova, N.S., and Omelchenko, S.O., Trace elements and nitrosamines concentration in black sea elasmobranch species, Asian J. Biol. Life Sci, 2012, vol. 1, no. 1, pp. 51– 57.
Rudneva, I.I., Melnikova, E.B., and Omelchenko, S.O., Seasonal variations of nitrosamine content in some black sea fish species, Turk. J. of Fish. Aquat. Sci, 2008, vol. 8, no. 2, pp. 283– 287.
Singh, P., Singhb, M.K., Bega, Y.R., and Nisha, G.R., A review on spectroscopic methods for determination of nitrite and nitrate in environmental samples, Talanta, 2019, vol. 191, pp. 364–381.
Stefanakis, A.I. and Becker, J.A., A review of emerging contaminants in water: classification, sources, and potential risks, Waste Management: Concepts, Methodologies, Tools, and Applications. Hershey, Pennsylvania: IGI Global USA, 2020, pp. 26–37.
Verstraete, W., Van de Caveyea, P., and Diamantis, V., Maximum use of resources present in domestic “used “water,” Bioresour. Technol, 2009, vol. 100, pp. 5537–5545.
Wang, Z., Zhang, B., Borthwick, A.G.L., Feng, C., Ni, J., Utilization of single-chamber microbial fuel cells as renewable power sources for electrochemical degradation of nitrogen-containing organic compounds. Chem. Eng. J., 2015. vol. 280. P. 99–105.
Wang, Z., Zheng, J., Tang, J., Wang, X., and Wu, Z., A pilot-scale forward osmosis membrane system for concentrating low-strength municipal wastewater: performance and implications, Scientific Reports, 2016. Article number 21 653.
Wood, M., Kajimura, M., Mommsen, T., and Waish, P., Alkaline tide and nitrogen conservation after feeding in an elas (Squalus acanthias), J. Exp. Biol, 2005, vol. 208, no. 14, pp. 2693–2705.
Yurchenko V.V., Molder U. Volatile N-Nitrosamines in various fish products. Food Chem. 2006. vol. 96, pp. 325–333.
The study was carried out on the theme of State Task of Federal Research Center A.O. Kovalevsky Institute of Biology of Southern Seas, Russian Academy of Sciences “Functional, metabolic and toxicological aspects of existence of hydrobionts and their populations in the biotopes with various physico-chemical regimes” (State Registry АААА-А18-118021490093-4).
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Rudneva, I.I., Omel’chenko, S.O. Nitrosamines in Aquatic Ecosystems: Sources, Formation, Toxicity, Environmental Risk (Review) 1. Structure, Properties, Ways of Entering and Formation in Waterbodies. Water Resour 48, 92–101 (2021). https://doi.org/10.1134/S0097807821010255