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Constants of acid‒base equilibria in an aqueous amikacin aminoglycoside solution at 298 K

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Abstract

The acid dissociation constants of form pK 1 = 7.34 ± 0.01, pK 2 = 7.84 ± 0.01, pK 3 = 8.77 ± 0.01, pK 4 = 9.49 ± 0.01, and pK 5 = 10.70 ± 0.02 of cationic amikacin are determined by pH-metric titration at 25°C against the background of 0.1 mol/L KNO3. K 1, K 2, K 3, and K 4 correspond to the dissociation of protons coordinated to amino groups, while K 5 characterizes the dissociation of the hydroxyl hydrogen atom, testifying to the amphoteric character of amikacin molecules. Applying density functional theory (DFT) with the B3LYP hybrid functional and the 6-311G**++ basis set, the partial charges on the atoms of an amikacin molecule are calculated. It is concluded that the dissociation of H(55)hydrogen atom occurs with a greatest partial charge of +0.53631.

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Authors and Affiliations

  1. Tver State University, Tver, 170100, Russia

    V. G. Alekseev

  2. St. Petersburg State Technological University of Plant Polymers, St. Petersburg, 198095, Russia

    E. V. Markova

Authors
  1. V. G. Alekseev
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  2. E. V. Markova
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Correspondence to V. G. Alekseev.

Additional information

Original Russian Text © V.G. Alekseev, E.V. Markova, 2016, published in Zhurnal Fizicheskoi Khimii, 2016, Vol. 90, No. 3, pp. 380–385.

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Alekseev, V.G., Markova, E.V. Constants of acid‒base equilibria in an aqueous amikacin aminoglycoside solution at 298 K. Russ. J. Phys. Chem. 90, 586–591 (2016). https://doi.org/10.1134/S0036024416020035

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  • DOI: https://doi.org/10.1134/S0036024416020035

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