Abstract
It is shown that the activity of the water-soluble porphyrin photosensitizer dimegine (DMG) in the oxidation reaction of tryptophan, a test reaction for photodynamic therapy (PDT), can be enhanced by introducing silver, gold, and hydroxyapatite nanoparticles (NP) into the reaction medium if an amphiphilic polymer (AP) with the properties of a SAS is introduced into this mixture. It is concluded that the effect of enhancing the photosensitizing activity of dimegine is due to the formation of nanoparticle-Pluronic-porphyrin triple systems in which Pluronic (PL) plays the role of a bridge, forming complex and adsorption bonds with porphyrin and nanoparticles.
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Original Russian Text © N.A. Aksenova, V.V. Kardumyan, N.N. Glagolev, V.T. Shashkova, I.A. Matveeva, P.S. Timashev, A.B. Solov’eva, 2015, published in Zhurnal Fizicheskoi Khimii, 2015, Vol. 89, No. 8, pp. 1322–1328.
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Aksenova, N.A., Kardumyan, V.V., Glagolev, N.N. et al. Effect of Pluronic F127 on the photosensitizing properties of dimegine in the presence of nanoparticles. Russ. J. Phys. Chem. 89, 1486–1491 (2015). https://doi.org/10.1134/S0036024415080026
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DOI: https://doi.org/10.1134/S0036024415080026