Present paper reports the measured densities (ρ) and refractive indices (n D) of aqueous solutions of Duloxetine drug in wide range of molal concentrations (m = 0.0101–0.1031 mol kg−1) and at different temperatures (297.15, 302.15, and 307.15 K). Apparent molar volumes (φv) of drug were calculated from density data and fitted to Masson’s relation \((\phi _\nu = \phi _\nu ^0 + S_\nu ^* \sqrt c )\) and partial molar volumes (φ 0v ) were evaluated at different temperatures. Concentration dependence of refractive index (n D = Kc + n 0D ) at experimental temperature has been studied. Density and refractive index data has been used for the calculation of specific refractions (R D). Experimental (ρ and n D) and calculated (φv, φ 0v , and R D) properties have been interpreted in terms of concentration and temperature effects on structural fittings and drug-water interactions.
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Deosarkar, S.D., Deoraye, S.M. & Kalyankar, T.M. Temperature and concentration dependences of density and refraction of aqueous duloxetine solutions. Russ. J. Phys. Chem. 88, 1129–1132 (2014). https://doi.org/10.1134/S0036024414070139
- molecular interactions
- drug-solvent interactions
- apparent molar volume