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Temperature and concentration dependences of density and refraction of aqueous duloxetine solutions

Russian Journal of Physical Chemistry A volume 88, pages 1129–1132 (2014)Cite this article

Abstract

Present paper reports the measured densities (ρ) and refractive indices (n D) of aqueous solutions of Duloxetine drug in wide range of molal concentrations (m = 0.0101–0.1031 mol kg−1) and at different temperatures (297.15, 302.15, and 307.15 K). Apparent molar volumes (φv) of drug were calculated from density data and fitted to Masson’s relation \((\phi _\nu = \phi _\nu ^0 + S_\nu ^* \sqrt c )\) and partial molar volumes (φ 0v ) were evaluated at different temperatures. Concentration dependence of refractive index (n D = Kc + n 0D ) at experimental temperature has been studied. Density and refractive index data has been used for the calculation of specific refractions (R D). Experimental (ρ and n D) and calculated (φv, φ 0v , and R D) properties have been interpreted in terms of concentration and temperature effects on structural fittings and drug-water interactions.

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Authors and Affiliations

  1. School of Chemical Sciences, Swami Ramanand Teerth Marathwada University, Nanded, 431 606, MS, India

    S. D. Deosarkar & S. M. Deoraye

  2. School of Pharmacy, Swami Ramanand Teerth Marathwada University, Nanded, 431 606, MS, India

    T. M. Kalyankar

Authors
  1. S. D. Deosarkar
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  2. S. M. Deoraye
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  3. T. M. Kalyankar
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Correspondence to S. D. Deosarkar.

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Deosarkar, S.D., Deoraye, S.M. & Kalyankar, T.M. Temperature and concentration dependences of density and refraction of aqueous duloxetine solutions. Russ. J. Phys. Chem. 88, 1129–1132 (2014). https://doi.org/10.1134/S0036024414070139

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  • DOI: https://doi.org/10.1134/S0036024414070139

Keywords

  • molecular interactions
  • drug-solvent interactions
  • duloxetine
  • apparent molar volume