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Analyzing the adsorption of blood plasma components by means of fullerene-containing silica gels and NMR spectroscopy in solids

Russian Journal of Physical Chemistry A volume 86, pages 1583–1587 (2012)Cite this article

Abstract

The results from studying the adsorption of blood plasma components (e.g., protein, triglycerides, cholesterol, and lipoproteins of low and high density) using silica gels modified with fullerene molecules (in the form of C60 or the hydroxylated form of C60(OH) x ) and subjected to hydration (or, alternatively, dehydration) are presented. The conditions for preparing adsorbents that allow us to control the adsorption capacity of silica gel and the selectivity of adsorption toward the components of blood plasma, are revealed. The nature and strength of the interactions of the introduced components (fullerene molecules and water) with functional groups on the silica surface are studied by means of solid state NMR spectroscopy (NMR-SS). Conclusions regarding the nature of the centers that control adsorption are drawn on the basis of NMR-SS spectra in combination with direct measurements of adsorption. The interaction of the oxygen of the hydroxyl group of silica gel with fullerene, leading to the formation of electron-donor complexes of C60-H, C60-OH, or C60-OSi type, is demonstrated by the observed changes in the NMR-SS spectra of silica gels in the presence of fullerene.

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Authors and Affiliations

  1. Institute of Macromolecular Compounds, St. Petersburg, 199004, Russia

    E. Yu. Melenevskaya, M. V. Mokeev, K. V. Nasonova & A. V. Gribanov

  2. Institute of Analytical Instrumentation, St. Petersburg, 190103, Russia

    N. G. Podosenova

  3. Ioffe Physicotechnical Institute, St. Petersburg, 194021, Russia

    L. V. Sharonova

Authors
  1. E. Yu. Melenevskaya
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  2. M. V. Mokeev
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  3. K. V. Nasonova
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  4. N. G. Podosenova
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  5. L. V. Sharonova
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  6. A. V. Gribanov
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Correspondence to E. Yu. Melenevskaya.

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Original Russian Text © E.Yu. Melenevskaya, M.V. Mokeev, K.V. Nasonova, N.G. Podosenova, L.V. Sharonova, A.V. Gribanov, 2012, published in Zhurnal Fizicheskoi Khimii, 2012, Vol. 86, No. 10, pp. 1686–1690.

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Melenevskaya, E.Y., Mokeev, M.V., Nasonova, K.V. et al. Analyzing the adsorption of blood plasma components by means of fullerene-containing silica gels and NMR spectroscopy in solids. Russ. J. Phys. Chem. 86, 1583–1587 (2012). https://doi.org/10.1134/S0036024412100172

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  • DOI: https://doi.org/10.1134/S0036024412100172

Keywords

  • Sorption
  • blood plasma
  • silica
  • fullerene
  • hydroxylated fullerene
  • NMR-SS