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The kinetics of oxidation of bilirubin and ascorbic acid in solution

  • Chemical Kinetics and Catalysis
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Abstract

The results of a comparative study of the oxidation of bilirubin, ascorbic acid, and their mixture in aqueous solutions under the action of air oxygen and hydrogen peroxide are presented. The observed and true rate constants for the oxidation reactions were determined. It was shown that the oxidation of tetrapyrrole pigment occurred under these conditions bypassing the stage of biliverdin formation to monopyrrole products. Simultaneous oxidation of bilirubin and ascorbic acid was shown to be accompanied by the inhibition of ascorbic acid oxidation by bilirubin, whereas ascorbic acid itself activated the oxidation of bilirubin.

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Authors and Affiliations

  1. Ivanovo State University of Chemical Technology, Ivanovo, Russia

    A. V. Solomonov, E. V. Rumyantsev & B. A. Kochergin

  2. Krestov Institute of the Solution Chemistry, Russian Academy of Sciences, Ivanovo, Russia

    E. V. Antina

Authors
  1. A. V. Solomonov
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  2. E. V. Rumyantsev
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  3. B. A. Kochergin
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  4. E. V. Antina
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Corresponding author

Correspondence to E. V. Rumyantsev.

Additional information

Original Russian Text © A.V. Solomonov, E.V. Rumyantsev, B.A. Kochergin, E.V. Antina, 2012, published in Zhurnal Fizicheskoi Khimii, 2012, Vol. 86, No. 7, pp. 1162–1167.

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Solomonov, A.V., Rumyantsev, E.V., Kochergin, B.A. et al. The kinetics of oxidation of bilirubin and ascorbic acid in solution. Russ. J. Phys. Chem. 86, 1048–1052 (2012). https://doi.org/10.1134/S0036024412070266

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  • DOI: https://doi.org/10.1134/S0036024412070266

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