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Intermolecular interactions in the bilirubin-cholate-silica system

  • Biophysical Chemistry
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Abstract

Bilirubin-cholate interactions in aqueous solutions were studied. The constants of binding of bilirubin with taurocholate dimers and taurodeoxycholate trimers were calculated. The adsorption of bilirubin and cholates on the surface of highly dispersed silica was studied. It was shown that taurine-conjugated cholates are poorly adsorbed from micellar solutions on the silica surface, the specific amount of bilirubin adsorbed decreases with increasing concentration of cholates in the solution, the affinity of free bilirubin for the silica surface is independent of the nature of the cholic acid, and that the affinity of cholate-bilirubin complexes for the silica surface is lower than the affinity of free bilirubin.

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Authors and Affiliations

  1. Institute of Surface Chemistry, National Academy of Sciences of Ukraine, ul. Generala Naumova 17, Kiev, 03164, Ukraine

    N. N. Vlasova, L. P. Golovkova & O. V. Severinovskaya

Authors
  1. N. N. Vlasova
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  2. L. P. Golovkova
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  3. O. V. Severinovskaya
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Additional information

Original Russian Text © N.N. Vlasova, L.P. Golovkova, O.V. Severinovskaya, 2007, published in Zhurnal Fizicheskoi Khimii, 2007, Vol. 81, No. 6, pp. 1136–1139.

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Vlasova, N.N., Golovkova, L.P. & Severinovskaya, O.V. Intermolecular interactions in the bilirubin-cholate-silica system. Russ. J. Phys. Chem. 81, 995–998 (2007). https://doi.org/10.1134/S0036024407060271

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  • DOI: https://doi.org/10.1134/S0036024407060271

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