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Synthesis and Characterization of 3-Hydroxy-2-(5'-Hydroxypentyl)-4H-Pyran-4-one and Study of Its Complexation with Iron(III)

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Abstract

With the special focus to obtain a new tridentate ligand able to coordinate Fe(III), 3-hydroxy-2-(5'-hydroxypentyl)-4H-pyran-4-one (5-H) has been synthesized. Iron/ligand solution chemistry has been investigated in aqueous solution by ESI-MS and cyclic voltammetric measurements. The physiologic predominant specie is the tris-chelate complex as Job test attested. The electrode potential of the [FeIII(5)3]/[FeII(5)3]– couple was evaluated to be –0.54 V vs. SCE, pH 7.4.

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ACKNOWLEDGMENTS

The authors acknowledge Prof. Marco Ferrali for his stimulating idea.

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  1. Department of Biotechnology, Chemistry and Pharmacy University of Siena, 53100, Siena, Italy

    M. Corsini & S. Fusi

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  1. M. Corsini
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  2. S. Fusi
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Corsini, M., Fusi, S. Synthesis and Characterization of 3-Hydroxy-2-(5'-Hydroxypentyl)-4H-Pyran-4-one and Study of Its Complexation with Iron(III). Russ. J. Inorg. Chem. 64, 1836–1840 (2019). https://doi.org/10.1134/S003602361914002X

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