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Hair follicle regeneration in vitro

Abstract

Hair follicles (HF) are skin appendages that develop as a result of the epithelial-mesenchymal interactions. The HF mesenchymal component—dermal papilla (DP)—has an ability to induce HF growth after transplantation in afollicular epidermis; this ability is retained through several passages in culture. In the present study, early regeneration events of a human HF are designed in vitro, using DP cells and skin kerati-nocytes. An artificial hair germ model is developed to study the primary steps of the stem cell self-organiza-tion during HF regeneration.

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Correspondence to E. P. Kalabusheva.

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Kalabusheva, E.P., Vorotelyak, E.A. Hair follicle regeneration in vitro. Paleontol. J. 50, 1656–1664 (2016). https://doi.org/10.1134/S0031030116140045

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  • DOI: https://doi.org/10.1134/S0031030116140045

Keywords

  • hair follicle
  • self-organization
  • dermal papilla
  • morphogenesis