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Optical Properties of Hyperosmotic Agents for Immersion Clearing of Tissues in Terahertz Spectroscopy

  • UV, IR, AND TERAHERTZ OPTICS
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Abstract

We measured the transmission spectra of the most common hyperosmotic agents, such as pure glycerol, propylene glycol (PG), dimethyl sulfoxide (DMSO), polyethylene glycol (PEG) with molecular weights of 200, 300, 400, and 600 Da, their aqueous solutions, and aqueous solutions of sucrose, glucose, fructose, and dextran 40 and 70. The experiments were carried out using a THz pulsed spectrometer with an evacuated measuring compartment to eliminate the effect of water vapor on spectral measurements. We reconstructed the dielectric characteristics of hyperosmotic agents in the spectral range from 0.1 to 2.5 THz and plotted a dependence of the amplitude absorption coefficient on the concentration of the considered agents at a frequency of 0.5 THz. The results are useful for selecting optimal agents for immersion optical clearing in the THz range.

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Funding

I.N. Dolganova developed the cuvette; this part was supported by the Grant of the President of the Russian Federation for the State Support of Young Russian Scientists—Candidates of Science (project no. MK-2541.2019.8). N.V. Chernomyrdin and V.V. Tuchin analyzed the absorption data for the solutions of agents with different concentrations, supported by the Russian Foundation for Basic Research (project no. 19-32-50075). V.V. Tuchin selected clearing agents with the support of the Russian Foundation for Basic Research (project no. 18-52-16025 NTsNIL_a).

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Authors and Affiliations

  1. Prokhorov General Physics Institute, Russian Academy of Sciences, 119991, Moscow, Russia

    G. R. Musina, A. A. Gavdush, N. V. Chernomyrdin, G. A. Komandin & K. I. Zaytsev

  2. Bauman Moscow State Technical University, 105005, Moscow, Russia

    G. R. Musina, A. A. Gavdush, N. V. Chernomyrdin, I. N. Dolganova, I. V. Zhivotovskii & K. I. Zaytsev

  3. Institute of Solid State Physics, Russian Academy of Sciences, 142432, Chernogolovka, Moscow oblast, Russia

    I. N. Dolganova, V. E. Ulitko & V. N. Kurlov

  4. Institute of Laser Physics, Siberian Branch, Russian Academy of Sciences, 630090, Novosibirsk, Russia

    O. P. Cherkasova

  5. National Research Tomsk State University, 634050, Tomsk, Russia

    O. P. Cherkasova & V. V. Tuchin

  6. Saratov State University, 410012, Saratov, Russia

    V. V. Tuchin

  7. Institute of Precision Mechanics and Control, Russian Academy of Sciences, 410028, Saratov, Russia

    V. V. Tuchin

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  1. G. R. Musina
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  2. A. A. Gavdush
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  3. N. V. Chernomyrdin
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  4. I. N. Dolganova
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  6. O. P. Cherkasova
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  7. V. N. Kurlov
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  8. G. A. Komandin
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  9. I. V. Zhivotovskii
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  10. V. V. Tuchin
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  11. K. I. Zaytsev
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Correspondence to G. R. Musina.

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Translated by O. Zhukova

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Musina, G.R., Gavdush, A.A., Chernomyrdin, N.V. et al. Optical Properties of Hyperosmotic Agents for Immersion Clearing of Tissues in Terahertz Spectroscopy. Opt. Spectrosc. 128, 1026–1035 (2020). https://doi.org/10.1134/S0030400X20070279

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