Skip to main content

Advertisement

SpringerLink
Log in

A Complex Approach to Noninvasive Estimation of Microcirculatory Tissue Impairments in Feet of Patients with Diabetes Mellitus using Spectroscopy

  • Geometrical and Applied Optics
  • Published:
Optics and Spectroscopy Aims and scope Submit manuscript

Abstract

The possibility of a complex approach for studying changes in the system of blood microcirculation and metabolic processes in the biotissue of lower extremities using optical noninvasive methods of laser doppler flowmetry (LDF), fluorescence spectroscopy, and diffuse reflectance spectroscopy in combination with different modes of heating tests has been assessed. Seventy-six patients with type 2 diabetes mellitus, with 14 patients having visible trophic foot impairments, and 48 healthy volunteers have been examined. The parameters of LDF signals and spectra of fluorescence intensity and diffuse reflectance for foot skin have been analyzed. Statistically significant differences in the recorded parameters between the groups under study have been found. It has been concluded that combined application of noninvasive methods of spectroscopy could be used for diagnostics of complications both upon the occurrence of preliminary symptoms of diabetes, when pathological changes are still reversible, and in the presence of impairments to prevent aggravation of the disease and select an adequate correction of the treatment.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. I. I. Dedov, Sakharn. Diabet, No. 3, 6 (2010).

    Google Scholar 

  2. V. V. Tuchin, Handbook of Optical Biomedical Diagnostics (Fizmatlit, Moscow, 2007; Soc. Photo Optical, 2016).

    Google Scholar 

  3. A. I. Krupatkin and V. V. Sidorov, Functional Diagnostics of the State of Microcirculatory–Tissue Systems: Oscillations, Information, Non-Linearity, Handbook (LIBROKOM, Moscow, 2013) [in Russian].

    Google Scholar 

  4. O. N. Bondarenko, N. L. Ayubova, G. R. Galstyan, and I. I. Dedov, Sakhar. Diabet, No. 1, 33 (2013).

    Google Scholar 

  5. V. B. Bregovskii, I. A. Karpova, and E. S. Lekseeva, Sakhar. Diabet, No. 3, 49 (2011).

    Google Scholar 

  6. N. A. Shor, Khirurgiya, No. 6, 29 (2001).

    Google Scholar 

  7. M. B. Antsiferov, G. R. Galstyan, A. Yu. Tokmakova, and I. I. Dedov, Sakhar. Diabet, No. 2, 2 (2001).

    Google Scholar 

  8. V. V. Dremin, V. V. Sidorov, A. I. Krupatkin, G. R. Galstyan, I. N. Novikova, A. I. Zherebtsova, E. A. Zherebtsov, A. V. Dunaev, Z. N. Abdulvapova, K. S. Litvinova, I. E. Rafailov, S. G. Sokolovski, and E. U. Rafailov, Proc. SPIE 9698, 969810 (2017). doi 10.1117/12.2212758

    Google Scholar 

  9. E. V. Potapova, V. V. Dremin, E. A. Zherebtsov, I. N. Makovik, A. I. Zherebtsova, A. V. Dunaev, K. V. Podmasteryev, V. V. Sidorov, A. I. Krupatkin, L. S. Khakhicheva, and V. F. Muradyan, Human Physiol. 43, 222 (2017). doi 0.1134/S036211971702013X

    Article  Google Scholar 

  10. N. Sujatha, B. S. Suresh Anand, K. Bala Nivetha, V. B. Narayanamurthy, V. Seshadri, and R. Poddar, J. Appl. Spectrosc. 82, 432 (2015). doi 10.1007/s10812-015-0125-9

    Article  ADS  Google Scholar 

  11. A. Nouvong, B. Hoogwerf, E. Mohler, B. Davis, A. Tajaddini, and E. Medenilla, Diabetes Care 32, 2056 (2009). doi 10.2337/dc08-2246

    Article  Google Scholar 

  12. B. S. Suresh Anand, N. Sujatha, V. B. Narayanamurthy, V. Seshadri, and R. Poddar, Opt. Lasers Eng. 53, 1 (2014). doi 10.1016/j.optlaseng.2013.07.020

    Article  Google Scholar 

  13. C. Lal and S. N. Unni, Med. Biol. Eng. Comput. 53, 557 (2015). doi 10.1007/s11517-015-1266-y

    Article  Google Scholar 

  14. A. A. Glazkov, D. A. Kulikov, A. V. Dreval’, Yu. A. Kovaleva, V. I. Shumskii, and D. A. Rogatkin, Al’man. Klin. Med., No. 31, 7 (2014).

    Google Scholar 

  15. V. V. Dremin, E. A. Zherebtsov, I. N. Makovik, I. O. Kozlov, V. V. Sidorov, A. I. Krupatkin, A. V. Dunaev, I. E. Rafailov, K. S. Litvinova, S. G. Sokolovski, and E. U. Rafailov, Proc. SPIE 10063, 1006303 (2017). doi 10.1117/12.2252427

    Article  Google Scholar 

  16. A. V. Dunaev, E. A. Zherebtsov, D. A. Rogatkin, N. A. Stewart, S. G. Sokolovski, and E. U. Rafailov, Proc. SPIE 8936, 89360D (2014). doi 10.1117/ 12.2035651

    ADS  Google Scholar 

  17. A. I. Zherebtsova, E. A. Zherebtsov, A. V. Dunaev, K. V. Podmasteryev, O. V. Pilipenko, A. I. Krupatkin, L. S. Khakhicheva, and V. F. Muradyan, Proc. SPIE 9917, 99170M (2016). doi 10.1117/12.2229827

    ADS  Google Scholar 

  18. S. J. Lin and L. Guarente, Curr. Opin. Cell Biol. 15, 241 (2003). doi 10.1016/S0955-0674(03)00006-1

    Article  Google Scholar 

  19. J. H. Hwang, D. W. Kim, E. J. Jo, Y. K. Kim, Y. S. Jo, J. H. Park, S. K. Yoo, M. K. Park, T. H. Kwak, Y. L. Kho, J. Han, H. S. Choi, S. H. Lee, J. M. Kim, I. Lee, T. Kyung, C. Jang, J. Chung, G. R. Kweon, and M. Shong, Diabetes 58, 965 (2009). doi 10.2337/db08-1183

    Article  Google Scholar 

  20. Y. Ido, C. Kilo, and J. R. Williamson, Diabetologia 40, S115 (1997). doi 10.1007/s001250051422

    Article  Google Scholar 

  21. A. Mayevsky and B. Chance, Mitochondrion. 7, 330 (2007). doi 10.1016/j.mito.2007.05.001

    Article  Google Scholar 

  22. A. Mayevsky and G. G. Rogatsky, AJP Cell Physiol. 292, C615 (2006). doi 10.1152/ajpcell.00249.2006

    Article  Google Scholar 

  23. E. T. Obi-Tabot, L. M. Hanrahan, R. Cachecho, E. R. Beer, S. R. Hopkins, J. C. Chan, J. M. Shapiro, and W. W. LaMorte, J. Surg. Res. 55, 575 (1993). doi 10.1006/jsre.1993.1187

    Article  Google Scholar 

  24. F. Bartolomé and A. Y. Abramov, Methods Mol. Biol. 1264, 263 (2015). doi 10.1007/978-1-4939-2257-4_23

    Article  Google Scholar 

  25. K. A. Foster, C. J. Beaver, and D. A. Turner, Neuroscience 132, 645 (2005). doi 10.1016/j.neuroscience. 2005.01.040

    Article  Google Scholar 

  26. I. J. Rampil, L. Litt, and A. Mayevsky, J. Clin. Monit. 8, 216 (1992). doi 10.1007/BF01616779

    Article  Google Scholar 

  27. G. Papayan, N. Petrishchev, and M. Galagudza, Photodiagn. Photodyn. Ther. 11, 400 (2014). doi 10.1016/ j.pdpdt.2014.05.003

    Article  Google Scholar 

  28. P. Gkogkolou and M. Böhm, Dermatoendocrinol. 4, 259 (2012). doi 10.4161/derm.22028

    Article  Google Scholar 

  29. R. Meerwaldt, R. Graaff, P. H. N. Oomen, T. P. Links, J. J. Jager, N. L. Alderson, S. R. Thorpe, J. W. Baynes, R. O. B. Gans, and A. J. Smit, Diabetologia 47, 1324 (2004). doi 10.1007/s00125-004-1451-2

    Article  Google Scholar 

  30. K. C. Tan, W. S. Chow, V. H. Ai, C. Metz, R. Bucala, and K. S. Lam, Diabetes Care 25, 1055 (2002). doi 10.2337/diacare.25.6.1055

    Article  Google Scholar 

  31. E. G. Gerrits, H. L. Lutgers, N. Kleefstra, R. Graaff, K. H. Groenier, A. J. Smit, R. O. Gans, and H. J. Bilo, Diabetes Care 31, 517 (2008). doi 10.2337/dc07-1755

    Article  Google Scholar 

  32. D. R. Sell, R. H. Nagaraj, S. K. Grandhee, P. Odetti, A. Lapolla, J. Fogarty, and V. M. Monnier, Diabetes. Metab. Rev. 7, 239 (1991). doi 10.1002/dmr.5610070404

    Article  Google Scholar 

  33. D. R. Sell, A. Lapolla, P. Odetti, J. Fogarty, and V. M. Monnier, Diabetes 41, 1286 (1992). doi 10.2337/ diab.41.10.1286

    Article  Google Scholar 

  34. M. Takahashi, H. Hoshino, K. Kushida, and T. Inoue, Anal. Biochem. 232, 158 (1995). doi 10.1006/ abio.1995.0002

    Article  Google Scholar 

  35. E. A. Zherebtsov, A. V. Bykov, A. P. Popov, A. Doronin, and I. V. Meglinski, Proc. SPIE 10063, 1006312 (2017). doi 10.1117/12.2250855

    Article  Google Scholar 

  36. J. W. Feather, Hajizadeh-M. Saffar, G. Leslie, and J. B. Dawson, Phys. Med. Biol. 34, 807 (1989). doi 10.1088/0031-9155/34/7/002

    Article  Google Scholar 

  37. M. Hajizadeh-Saffar, J. W. Feather, and J. B. Dawson, Phys. Med. Biol. 35, 1301 (1990). doi 10.1088/0031-9155/35/9/009

    Article  Google Scholar 

  38. O. A. Zyuryukina, I. A. Nakhaeva, R. Mokhammod, and Yu. P. Sinichkin, in Proceedings of the 17th International Young Scientists School on Problems of Optical Physics and Biophotonics SFM-2013, p.9.

  39. V. V. Dremin, E. A. Zherebtsov, I. E. Rafailov, A. Y. Vinokurov, I. N. Novikova, A. I. Zherebtsova, K. S. Litvinova, and A. V. Dunaev, Proc. SPIE 9917, 99170Y (2016). doi 10.1117/12.2229451

    Article  ADS  Google Scholar 

  40. E. A. Zherebtsov, K. Y. Kandurova, E. S. Seryogina, I. O. Kozlov, V. V. Dremin, A. I. Zherebtsova, A. V. Dunaev, and I. V. Meglinski, Proc. SPIE 10336, 1033608 (2017). doi 10.1117/12.2267957

    Article  Google Scholar 

  41. L. Xi, C.-M. Chow, and X. Kong, J. Diabetes Res. Hindawi 2016, 1 (2016). doi 10.1155/2016/1527852

    Article  Google Scholar 

  42. H. Thangarajah, D. Yao, E. I. Chang, Y. Shi, L. Jazayeri, I. N. Vial, R. D. Galiano, X. L. Du, R. Grogan, M. G. Galvez, M. Januszyk, M. Brownlee, and G. C. Gurtner, Proc. Natl. Acad. Sci. 106, 13505 (2009). doi 10.1073/pnas.0906670106

    Article  ADS  Google Scholar 

  43. J. Ditzel and E. Standl, Acta Med. Scand. Suppl. 578, 59 (1975). doi 10.1111/j.0954-6820.1975.tb06503.x

    Google Scholar 

  44. R. Bucala, K. J. Tracey, and A. Cerami, J. Clin. Invest. 87, 432 (1991). doi 10.1172/JCI115014

    Article  Google Scholar 

  45. A. W. Stitt, C. He, S. Friedman, L. Scher, P. Rossi, L. Ong, H. Founds, Y. M. Li, R. Bucala, and H. Vlassara, Mol. Med. 3, 617 (1997).

    Google Scholar 

  46. U. Chakravarthy, R. G. Hayes, W. Stitt, E. McAuley, and D. B. Archer, Diabetes 47, 945 (1998). doi 10.2337/diabetes.47.6.945

    Article  Google Scholar 

  47. D. P. Stephens, N. Charkoudian, J. M. Benevento, J. M. Johnson, and J. L. Saumet, Am. J. Physiol. Regul. Integr. Comp. Physiol. 281, R894 (2001).

    Article  Google Scholar 

  48. C. T. Minson, L. T. Berry, and M. J. Joyner, J. Appl. Physiol. 91, 1619 (2001).

    Article  Google Scholar 

  49. D. L. Kellogg, J. L. Zhao, Y. Wu, and Y. Wu, J. Appl. Physiol. Am. Physiol. Soc. 107, 1438 (2009). doi 10.1152/japplphysiol.00690.2009

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Orel State University Named after I.S. Turgenev, Orel, 302026, Russia

    E. V. Potapova, V. V. Dremin, E. A. Zherebtsov, I. N. Makovik, E. V. Zharkikh, A. V. Dunaev & O. V. Pilipenko

  2. Aston Institute of Photonic Technologies, School of Engineering and Applied Sciences, Aston University, B4 7ET, Birmingham, United Kingdom

    E. A. Zherebtsov

  3. LAZMA Scientific Production Enterprise, Moscow, 123458, Russia

    V. V. Sidorov

  4. Priorov Central Research Institute of Traumatology and Orthopaedics, Moscow, 127299, Russia

    A. I. Krupatkin

Authors
  1. E. V. Potapova
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. V. V. Dremin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. A. Zherebtsov
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. I. N. Makovik
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. E. V. Zharkikh
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. A. V. Dunaev
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. O. V. Pilipenko
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. V. V. Sidorov
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. A. I. Krupatkin
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to E. V. Potapova.

Additional information

Original Russian Text © E.V. Potapova, V.V. Dremin, E.A. Zherebtsov, I.N. Makovik, E.V. Zharkikh, A.V. Dunaev, O.V. Pilipenko, V.V. Sidorov, A.I. Krupatkin, 2017, published in Optika i Spektroskopiya, 2017, Vol. 123, No. 6, pp. 946–956.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Potapova, E.V., Dremin, V.V., Zherebtsov, E.A. et al. A Complex Approach to Noninvasive Estimation of Microcirculatory Tissue Impairments in Feet of Patients with Diabetes Mellitus using Spectroscopy. Opt. Spectrosc. 123, 955–964 (2017). https://doi.org/10.1134/S0030400X1712013X

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1134/S0030400X1712013X

Search

Navigation