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Polymorphism of the c-fms, ITGB3, CCR2, and DBH genes in the populations of old believers of the Tyumen oblast and Russian residents of Novosibirsk

  • Genomics. Transcriptomics
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Abstract

Old Believers of the Tyumen oblast have been studied compared with a control sample of Russian residents of the city of Novosibirsk. The former are a unique subpopulation, which has been relatively isolated from the rest of Russians in central and northern regions of Russia due to religious reasons since the middle of the 17th century. Polymorphisms in the genes for glycoprotein ITGB3, dopamine-β-hydroxylase (DBH), and chemokine receptor CCR2 and two mutations in the c-fms gene have been analyzed. The populations are only similar in the c-fms indel. The frequencies of the rare alleles of CCR2, ITGB3, and 3'UTR of c-fms in the Old Believers are lower than in the sample of Novosibirsk Russians, and the rare allele of DBH is more frequent. A significant negative correlation is observed between DBH and CCR2 (r =–0.88; df = 4; P < 0.023). Apparently, these differences are related to the long-term isolation of Old Believers. This assumption is consistent with the fact that the levels of heterozygosity for most loci in Old Believers are lower than in Novosibirsk Russians.

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References

  1. Orekhov V., Poltoraus A., Zhivotovsky L., Spitsyn V., Ivanov P., Yankovsky N. 1999. Mitochondrial DNA sequence diversity in Russians. FEBS Letters. 445, 197–201.

    Article  CAS  PubMed  Google Scholar 

  2. Malyarchuk B.A., Denisova G.A., Derenko M.V., Rogaev E.I., Vlasenko L.V., Zhukova S.G. 2001. Mitochondrial DNA variation in Russian populations of Krasnodar krai, Belgorod, and Nizhny Novgorod oblast. Russ. J. Genet. 37 (10), 1185–1189.

    Article  CAS  Google Scholar 

  3. Malyarchuk B.A., Derenko M.V., Grzybowski T., Charnyi Ya., Miscicka-Slivka D., Denisova G.A., and Kostyunina E.A. 2002. Mitochondrial DNA variation in Russian populations of Stavropol Krai, Orel and Saratov oblasts. Russ. J. Genet. 38 (11), 1298–1303.

    Article  CAS  Google Scholar 

  4. Malyarchuk B.A., Derenko M.V., Denisova G.A., Nassiri M.R., Rogaev E.I. 2002. Mitochondrial DNA polymorphism in populations of the Caspian region and southeastern Europe. Russ. J. Genet. 38 (4), 434–438.

    Article  CAS  Google Scholar 

  5. Malyarchuk B., Grzybowski T., Derenko M., Czarny J., Wozniak M., Miscicka-Sliwka D. 2002. Mitochondrial DNA variability in Poles and Russians. Ann. Hum. Genet. 66, 261–283.

    Article  CAS  PubMed  Google Scholar 

  6. Malyarchuk B., Grzybowski T., Derenko M., Perkova M., Vanecek T., Lazur J., Gomolcak P., Tsybovsky I. 2008. Mitochondrial DNA phylogeny in Eastern and Western slavs. Mol. Biol. Evol. 25, 1651–1658.

    Article  CAS  PubMed  Google Scholar 

  7. Lunkina A.V., Denisova G.A., Derenko M.V., Malyarchuk B.A. 2004. Mitochondrial DNA variation in two Russian populations from Novgorod oblast. Russ. J. Genet. 40 (7), 795–799.

    Article  CAS  Google Scholar 

  8. Morozova I.Yu., Naumova O.Yu., Rychkov S.Yu., Zhukova O.V. 2005. Mitochondrial DNA polymorphism in Russian population form five oblasts of the European part of Russia. Russ. J. Genet. 41 (9), 1040–1045.

    Article  CAS  Google Scholar 

  9. Grzybowski T., Malyarchuk B., Derenko M., Perkova M., Bednarek J., Wozniak M. 2007. Complex interactions of the Eastern and Western Slavic populations with other European groups as revealed by mitochondrial DNA analysis. Forensic Sci. Int.: Genetics. 1, 141–147.

    Article  Google Scholar 

  10. Sukernik R.I., Volod’ko N.V., Mazunin I.O., El’tsov N.P., Starikovskaya E.B. 2010. The genetic history of Russian settlers of polar Northeastern Siberia. Russ. J. Genet. 46 (11), 1386–1394.

    Article  CAS  Google Scholar 

  11. Morozova I., Evsykov A., Kon’kov A., Grosheva A., Zhukova O., Rychkov S. 2012. Russian ethnic history inferred from mitochondrial DNA diversity. Am. J. Phys. Antropol. 147, 341–351.

    Article  Google Scholar 

  12. Rubinstein S., Dulik M.C., Gokcumen O., Zhadanov S., Osopova L., Cocca M., Mehta N., Gubina M., Posukh O., Schurr T.G. 2008. Russian old believers: Genetic consequences of their persecution and exile, as shown by mitochondrial DNA evidence. Hum. Biol. 80, 203–237.

    Article  PubMed  Google Scholar 

  13. Calafell F., Underhill P., Tolun A., Angelicheva D., Kalaydjieva L. 1996. From Asia to Europe: Mitochondrial DNA sequence variability in Bulgarians and Turks. Ann. Hum. Genet. 60, 35–49.

    Article  CAS  PubMed  Google Scholar 

  14. Tolk H.V., Pericic M., Barac L., Klaric I.M., Janicijevic B., Rudan I., Parik., Villems R., Rudan P. 2000. MtDNA haplogroups in the populations of Croatian Adriatic Islands. Coll. Anthropol. 24, 267–279.

    CAS  Google Scholar 

  15. Belyaeva O., Bermisheva M., Khrunin A., Slominsky P., Bebyakova N., Khusnutdinova E., Mikulich A., Limborska S. 2003. Mitochondrial DNA variations in Russian and Belorussian populations. Hum. Biol. 75, 647–660.

    Article  PubMed  Google Scholar 

  16. Cvjetan S., Tolk H.V., Lauc L.B., Colak I., Dordevic D., Efremovska L., Lanicijevic B., Kvesic A., Klaric I.M., Metspalu E., Periciv M., Parik J., Popovic D., Sijacki A., Terzic R., et al. 2004. Frequencies of mtDNA haplogroups in southeastern Europe—Croatians, Bosnians and Herzegovinians, Serbians, Macedonians and Macedonian Romani. Coll. Antropol. 28, 193–198.

    CAS  PubMed  Google Scholar 

  17. Vanecek T., Vorel F., Sip M. 2004. Mitochondrial DNA D-loop hypervariable regions: Czech population data. Int. J. Legal Med. 118, 14–18.

    Article  CAS  PubMed  Google Scholar 

  18. Zupanic Pajnic I., Balazic J., Komel R. 2004. Sequence polymorphism of the mitochondrial DNA control region in the Slovenian population. Int. J. Legal Med. 118, 1–4.

    Article  CAS  PubMed  Google Scholar 

  19. Malyarchuk B.A. 2001. Differentiation and genetic position of Slavs among Eurasian ethnoses as inferred from variation in mitochondrial DNA. Russ. J. Genet. 37 (12), 1437–1443.

    Article  CAS  Google Scholar 

  20. Nikitin A.G. Potapov V.A., Brovkin A.N., Lavrikova E.Yu., Khodyrev D.S., Shamkhalova M.Sh., Smetanina S.A., Suplotova L.N., Shestakova M.V., Nosikov V.V., Aver’yanov A.V. 2015. Association of FTO, KCNJ11, SLC30A8, and CDKN2B polymorphisms with type 2 diabetes mellitus. Mol. Biol. (Moscow). 49 (1), 103–111.

    Article  CAS  Google Scholar 

  21. Solovieva D.S., Balanovskaya E.V., Kuznetsova M.A., Vasinskaya O.A., Frolova S.A., Pocheshkhova E.A., Evseeva I.V., Boldyreva M.N., Balanovsky O.P. 2010. The Russian gene pool: The gene geography of Alu insertions (ACE, APOA1, B65, PV92, TPA25). Mol. Biol. (Moscow). 44 (3), 393–400.

    Article  CAS  Google Scholar 

  22. Kofiadi I.A., Rebrikov D.V., Trofimov D.Yu., Alekseev L.P., Khaitov R.M. 2007. Allelic distribution of the CCR5, CCR2, and SDF1 gene polymorphismsassociated with HIV-1/AIDS resistance in Russian populations. Dokl. Biol. Sci. 415, 320–323.

    Article  CAS  PubMed  Google Scholar 

  23. Voevoda M.I., Kulikov I.V., Maksimov V.N. 2009. Instant cardiac death and polymorphism in candidate genes associated for cardiovascular diseases. Kardiologiya. 49, 52–57.

    CAS  PubMed  Google Scholar 

  24. Cherkashina I.I., Nikulina S.Yu., Logvinenko N.I., Shul’man V.A., Shestovitskii V.A., Voevoda M.I., Maksimov V.N., Chernova A.A. 2013. Analysis of polymorphism in the CCR2 chemokine receptor gene in patients with bronchial asthma and chronic obstructive pulmonary disease. Pul’monologiya. 1, 20–24.

    Google Scholar 

  25. Egorova N.E., Logvinenko N.I., Maksimov V.N. 2007. 17-yi Natsional’nyi kongress po boleznyam organov dykhaniya. Tezisy (Abstracts of 17th National Congress on Diseases of Respiratory Organs). Kazan, p.96.

    Google Scholar 

  26. Puzyrev V.P., Stepanov V.A., Freidin M.B. 2005. Molecular basses of widespread multifactor diseases. In: Genomika—meditsine (Genomics for Medicine). Moscow: Akadmkniga, pp. 100–137

    Google Scholar 

  27. Voevoda M.I., Ustinov S.N., Yudin N.S., Dolgikh M.M., Kuznetsova T.T., Maksimov V.N., Kulikov I.V., Gromov A.V., Shabalin A.V., Semaeva E.V., Kobzev V.F., Vaum S.R., Gafarov V.V., Malyutina S.K., Romashchenko A.G., Nikitin Yu.P. 2002. Association of the CCR2 chemokine receptor gene polymorphism with myocardial infarction. Dokl. Biol. Sci. 385, 367–370.

    Article  CAS  PubMed  Google Scholar 

  28. Solov’eva I.G., Gubina M.A., Romashchenko A.G., Cherenkova M.M., Ponebratets O.Yu., Shirokov R.V., Abramova T.Ya., Sidorov S.V., Cherdyntseva N.V., Kozlov V.A. 2011. Polymorphism of the dopamine β-hydroxylase gene, parameters of vegetative regulation, and and clinical–pathological characteristics of malignant process in patients with stomach cancer. Sib. Onkol. Zh. 5, 46–51.

    Google Scholar 

  29. Nikolsky N.M. 1961. The History of the Russian Church, 2nd ed. Moscow: Prosveshchenie.

    Google Scholar 

  30. Bunak V.V., Zolotareva I.M. 1973. Russkie starozhily Sibiri. Istoriko-antropologicheskii ocherk (Russian Oldtimers in Siberia: A Hostorical Anthropological Essay). Moscow: Nauka.

    Google Scholar 

  31. Gubina M.A., Babenko V.N., Damba L.D., Ponomareva M.N., Konovalova N.A., Voevoda M.I. 2014. Polymorphism of mitochondrial DNA in Old Believers from Siberia. Russ. J. Genet. 50 (6), 638–652.

    Article  CAS  Google Scholar 

  32. Maniatis T., Fritsch E.E., Sambrook J. 1982. Molecular Cloning: A Laboratory Manual. NY: Cold Spring Harbor Lab. Press.

    Google Scholar 

  33. Kouznetsova T.N., Voevoda M.I., Podkolodnaya O.A., Kulikov I.V., Kobzev V.F., Ustinov S.N., Malyutina S.K., Logvinenko N.I., Zhuravskaya E.Ya., Cherdyntseva N.V., Tumanov Yu.V., Morozova O.A., Baum V.A., Romashchenko A.G. 2004. Deletion polymorphism of the human c-fms gene intron 11: Allelic frequencies in some populations of Russia and possible functional significance. Russ. J. Genet. 40 (1), 86–95.

    Article  CAS  Google Scholar 

  34. Romashchenko A.G., Kuznetsova T.N., Ruzankina Ya.S., Kostenko M.V., Kobzev V.F., Kulikov I.V., Konchuk Ch., Voevoda M.I. 2002. Detection of two polymorphic sites in the human c-fms gene: Allele frequencies in several Russian populations. Russ. J. Genet. 38 (1), 33–40.

    CAS  Google Scholar 

  35. Feng D., Lindpaintner K., Larson M.G., Rao V.S., O’Donnell C.J., Lipinska I., Schmitz C., Sutherland P.A., Silbershatz H., D’Agostino R.B., Muller J.E., Myers R.H., Levy D., Tofler G.H. 1999. Increased platelet aggregability associated with platelet GPIIIa PlA2 polymorphism: The Framingham Offspring Study. Arterioscler. Thromb. Vasc. Biol. 19, 1142–1147.

    Article  CAS  PubMed  Google Scholar 

  36. Vijayan K.V., Liu Y., Dong J.F., Bray P.F. 2003. Enhanced activation of mitogen-activated protein kinase and myosin light chain kinase by the Pro33 polymorphism of integrin beta 3. J. Biol. Chem. 278, 3860–3867.

    Article  CAS  PubMed  Google Scholar 

  37. Cubells J.F., van Kammen D.P., Kelley M.E., Anderson G.M., O’Connor D.T., Price L.H., Malison R., Rao P.A., Kobayashi K., Nagatsu T., Gelernter J. 1998. Dopamine beta-hydroxylase: Two polymorphisms in linkage disequilibrium at the structural gene DBH associate with biochemical phenotypic variation. Hum Genet. 102, 533–540.

    Article  CAS  PubMed  Google Scholar 

  38. Yamamoto K., Cubells J. F., Gelernter J., Benkelfat C., Lalonde P., Bloom D., Lal S., Labelle A., Turecki G., Rouleau G.A., Joober R. 2003. Dopamine betahydroxylase (DBH) gene and schizophrenia phenotypic variability: A genetic association study. Am. J. Med. Genet. 117B, 33–38.

    Article  PubMed  Google Scholar 

  39. Ortlepp J.R., Vesper K., Mevissen V. Schmitz F., Janssens U., Franke A., Hanrath P., Weber C., Zerres K., Hoffmann R. 2003. Chemokine receptor (CCR2) genotype is associated with myocardial infarction and heart failure in patients under 65 years of age. J. Mol. Med. 81, 363–367.

    Article  CAS  PubMed  Google Scholar 

  40. Slatkin M. 1994. An exact test for neutrality based on the Ewens sampling distribution. Genet. Res. 64, 71–74.

    Article  CAS  PubMed  Google Scholar 

  41. Excoffier L., Laval G., Schneider S. 2005. Arlequin (version 3.0): An integrated software package for population genetics dataanalysis. Evol. Bioinform. Online. 1, 47–50.

    CAS  PubMed Central  Google Scholar 

  42. www.Addinsoft.com

  43. Malyarchuk B.A., Perkova M.A., Derenko M.V. 2008. On the origin of Mongoloid component in the mitochondrial gene pool of Slavs. Russ. J. Genet. 44 (3), 344–349.

    Article  CAS  Google Scholar 

  44. Su B., Sun G., Lu D. 2000. Distribution of three HIV-1 resistance-conferring polymorphisms (SDF1-3'A, CCR2-641, and CCR5-delta32) in global populations. Eur. J. Hum. Genet. 8, 975–979.

    Article  CAS  PubMed  Google Scholar 

  45. Wagner K.R., Giles W.H., Johnson C.J., Ou C.Y., Bray P.F., Goldschmidt-Clermont P.J., Croft J.B., Brown V.K., Stern B.J., Feeser B.R., Buchholz D.W., Earley C.J., Macko R.F., McCarter R.J., Sloan M.A., et al. 1998. Platelet glycoprotein receptor IIIa polymorphism P1A2 and ischemic stroke risk: The stroke prevention in young women study. Stroke. 29, 581–585.

    Article  CAS  PubMed  Google Scholar 

  46. Anderson J.L., King G.J., Bair T.L., Elmer S.P., Muhlestein J.B., Habashi J., Carlquist J.F. 1999. Associations between a polymorphism in the gene encoding glycoprotein IIIa and myocardial infarction or coronary artery disease. J. Am. Coll. Cardiol. 33, 727–733.

    Article  CAS  PubMed  Google Scholar 

  47. Weinshilboum R., Axelrod J. 1971. Serum dopaminebeta-hydroxylase activity. Circ. Res. 28, 307–315.

    Article  CAS  PubMed  Google Scholar 

  48. Weinshilboum R.M., Schorott H.G., Raymond F.A., Weidman W.H., Elveback L.R. 1975. Inheritance of very low serum dopamine-beta-hydroxylase activity. Am. J. Hum. Genet. 27, 573–585.

    CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia

    M. A. Gubina, V. N. Babenko, D. E. Ivanoshchuk, A. K. Shuryaeva, O. O. Latieva, V. N. Maksimov & M. I. Voevoda

  2. Novosibirsk State University, Novosibirsk, 630090, Russia

    A. K. Shuryaeva & O. O. Latieva

  3. Novosibirsk State Medical University, Novosibirsk, 630091, Russia

    I. G. Solov’eva

  4. Kurgan Regional Hospital for War Veterans, Kurgan, 640014, Russia

    M. N. Ponomareva

  5. Tyumen State Medical Academy, Tyumen, 625023, Russia

    N. A. Konovalova

  6. Institute of Internal Medicine, Siberian Branch of the Russian Academy of Medical Sciences, Novosibirsk, 630089, Russia

    D. E. Ivanoshchuk, V. N. Maksimov & M. I. Voevoda

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  1. M. A. Gubina
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  2. V. N. Babenko
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  3. D. E. Ivanoshchuk
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  4. A. K. Shuryaeva
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  5. O. O. Latieva
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  6. I. G. Solov’eva
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  7. M. N. Ponomareva
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  8. N. A. Konovalova
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  9. V. N. Maksimov
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  10. M. I. Voevoda
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Correspondence to M. A. Gubina.

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Original Russian Text © M.A. Gubina, V.N. Babenko, D.E. Ivanoshchuk, A.K. Shuryaeva, O.O. Latieva, I.G. Solov’eva, M.N. Ponomareva, N.A. Konovalova, V.N. Maksimov, M.I. Voevoda, 2016, published in Molekulyarnaya Biologiya, 2016, Vol. 50, No. 2, pp. 246–254.

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Gubina, M.A., Babenko, V.N., Ivanoshchuk, D.E. et al. Polymorphism of the c-fms, ITGB3, CCR2, and DBH genes in the populations of old believers of the Tyumen oblast and Russian residents of Novosibirsk. Mol Biol 50, 213–219 (2016). https://doi.org/10.1134/S0026893316010052

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