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EPHX1 Tyr113His polymorphism contributes to hepatocellular carcinoma risk: Evidence from a meta-analysis

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Abstract

To clarify the association between the microsomal epoxide hydrolase gene (EPHX1) Tyr113His polymorphism and the hepatocellular carcinoma (HCC) risk, a meta-analysis was performed. Through a literature search, 119 relevant records were identified, and 17 individual case-control studies from 13 publications were finally included, involving a total of 1480 HCC cases and 2564 controls. Overall, the EPHX1 Tyr113His polymorphism was associated with an increased risk of HCC. Subgroup analyses by the status of the Hardy-Weinberg equilibrium (HWE) in controls further confirmed this association. In subgroup analyses, increased associations were found in Asians, Caucasians, hepatitis B virus (HBV)-dominant areas, hepatitis C virus (HCV)-dominant areas, high and medium-rate areas of HCC, but not in Africans and low-rate areas of HCC, respectively. This meta-analysis suggests that EPHX1 Tyr113His polymorphism contributes to the HCC risk.

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Author information

Authors and Affiliations

  1. Department of Epidemiology and Biostatistics, School of Public Health, Hebei Medical University, Shijiazhuang, Hebei Province, 050017, China

    D. Wang & D. W. Liu

  2. Library, Hebei Medical University, Shijiazhuang, Hebei Province, 050017, China

    D. Wang

  3. Department of Novelty Retrieval, Institute of Hebei Medical Information, Shijiazhuang, Hebei Province, 050071, China

    J. X. Zhai

  4. Division of Cardiology, Guanganmen Hospital, China Academy of Chinese Medical Science, Beijing, 100053, China

    L. M. Zhang

  5. Department of Occupational and Environmental Health, School of Public Health, Hebei Medical University, Shijiazhuang, Hebei Province, 050017, China

    X. H. Liu

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  1. D. Wang
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  2. J. X. Zhai
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  3. L. M. Zhang
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  4. D. W. Liu
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  5. X. H. Liu
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Correspondence to D. Wang.

Additional information

Published in Russian in Molekulyarnaya Biologiya, 2015, Vol. 49, No. 2, pp. 351–361.

The article is published in the original.

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Wang, D., Zhai, J.X., Zhang, L.M. et al. EPHX1 Tyr113His polymorphism contributes to hepatocellular carcinoma risk: Evidence from a meta-analysis. Mol Biol 49, 312–321 (2015). https://doi.org/10.1134/S0026893315020156

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  • DOI: https://doi.org/10.1134/S0026893315020156

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