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Nonviral delivery systems for small interfering RNAs

  • Molecular Biomedicine Special Issue
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Abstract

RNA interference is now considered to be the most powerful and promising tool for gene-targeted therapy. Several problems are still to be solved for its successful use in medicine. One of the main issues is efficient siRNA delivery. The review considers various types of nonviral siRNA delivery systems.

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Abbreviations

DOPC:

1,2-dioleoyl-sn-glycero-3-phosphocholine

DOPE:

dioleoyl-L-α-phosphatidylethanolamine

DOTAP:

1,2-dioleoyl-3-thrimethylammonium propane

GFP:

green fluo-rescent protein

JRed:

red fluorescent protein

siRNA:

small interfering RNA

SWNT:

single-wall carbon nanotube

TNF-α:

tumor necrosis factor α

MRI:

magnetic resonance imaging

PEG:

polyethylene glycol

PEI:

polyethyleneimine

PAEI:

polyamidoethyleneimine

CD:

cyclodextrin

CDP:

β-cyclodextrin-containing polycations

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Authors and Affiliations

  1. Research Center for Medical Genetics, Russian Academy of Medical Sciences, Moscow, 115478, Russia

    K. V. Glebova, A. V. Marakhonov, A. V. Baranova & M. Yu. Skoblov

  2. School of Systems Biology, George Mason University, Fairfax, VA, 22003, USA

    A. V. Baranova

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  1. K. V. Glebova
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  2. A. V. Marakhonov
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  3. A. V. Baranova
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  4. M. Yu. Skoblov
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Original Russian Text © K.V. Glebova, A.V. Marakhonov, A.V. Baranova, M.Yu. Skoblov, 2012, published in Molekulyarnaya Biologiya, 2012, Vol. 46, No. 3, pp. 387-401.

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Glebova, K.V., Marakhonov, A.V., Baranova, A.V. et al. Nonviral delivery systems for small interfering RNAs. Mol Biol 46, 349–361 (2012). https://doi.org/10.1134/S0026893312020070

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