Molecular Biology

, Volume 46, Issue 3, pp 349–361 | Cite as

Nonviral delivery systems for small interfering RNAs

  • K. V. Glebova
  • A. V. Marakhonov
  • A. V. Baranova
  • M. Yu. Skoblov
Molecular Biomedicine Special Issue

Abstract

RNA interference is now considered to be the most powerful and promising tool for gene-targeted therapy. Several problems are still to be solved for its successful use in medicine. One of the main issues is efficient siRNA delivery. The review considers various types of nonviral siRNA delivery systems.

Keywords

RNA interference siRNA siRNA delivery 

Abbreviations

DOPC

1,2-dioleoyl-sn-glycero-3-phosphocholine

DOPE

dioleoyl-L-α-phosphatidylethanolamine

DOTAP

1,2-dioleoyl-3-thrimethylammonium propane

GFP

green fluo-rescent protein

JRed

red fluorescent protein

siRNA

small interfering RNA

SWNT

single-wall carbon nanotube

TNF-α

tumor necrosis factor α

MRI

magnetic resonance imaging

PEG

polyethylene glycol

PEI

polyethyleneimine

PAEI

polyamidoethyleneimine

CD

cyclodextrin

CDP

β-cyclodextrin-containing polycations

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Copyright information

© Pleiades Publishing, Ltd. 2012

Authors and Affiliations

  • K. V. Glebova
    • 1
  • A. V. Marakhonov
    • 1
  • A. V. Baranova
    • 1
    • 2
  • M. Yu. Skoblov
    • 1
  1. 1.Research Center for Medical GeneticsRussian Academy of Medical SciencesMoscowRussia
  2. 2.School of Systems BiologyGeorge Mason UniversityFairfaxUSA

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