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The polymorphisms G(−174)C in IL6 gene and G(−1082)A in IL10 gene are associated with poor outcomes in patients with acute coronary syndrome

  • Genomics and Transcriptomics
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Abstract

Association between the rates of poor outcomes in the patient cohort with acute coronary syndrome and polymorphisms G(−174)C in the IL6 gene and G(−1082)A in the IL10 gene were determined. In total, 1145 patients hospitalized for coronary artery disease to cardiological hospitals of Moscow, St. Petersburg, Kazan, Chelyabinsk, Perm, Stavropol, and Rostov-on-Don were examined. The mean observation period was 9.10 ± 5.03 months (maximal, 18 months). Analysis of the survival of the patients with acute coronary syndrome that carried allele A has demonstrated that the presence of IL10 gene polymorphism G(−1082)A is associated with more frequent poor outcomes as compared with GG genotype. The survival time to endpoint for the carriers of GA and AA genotypes was 11.68 ± 0.67 months versus 12.69 ± 0.65 months for the carriers of GG genotype in IL10 gene (χ2 = 4.13, p = 0.042). As for the IL6 gene polymorphism G(−174)C, survival rate analysis did not detect any significant association with the risk for poor outcome. However, joint analysis of these polymorphisms in both genes has demonstrated that characteristic of the patients with acute coronary syndrome that carry GG genotype of IL6 gene and GA and AA genotypes of IL10 is a higher rate of poor outcomes (time to endpoint, 11.01 ± 1.24 months) as compared with the carriers of IL6 gene CC and CG genotypes and IL10 gene GG genotype (time to endpoint, 13.28 ± 0.83 months (ξ2 = 10.23, p = 0.017). These data suggest that the genes IL6 and IL10, whose products are involved in the control of inflammatory response, play an important role by increasing the probability of poor outcomes in the patients with acute coronary syndrome.

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Abbreviations

CAD:

coronary artery disease

MI:

myocardial infarction

UA:

unstable angina

ACS:

acute coronary syndrome

CVDs:

cardiovascular diseases

IL6 :

the gene coding for interleukin-6

IL10 :

the gene coding for interleukin-10

LDL:

low density lipoproteins

IS:

ischemic stroke

AH:

arterial hypertension

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Authors and Affiliations

  1. State Research Center GosNIIGenetika, Moscow, 117545, Russia

    K. A. Blagodatskikh, Yu. V. Agapkina, A. G. Nikitin, A. N. Brovkin, A. A. Pushkov & E. G. Blagodatskikh

  2. Educational and Research Center of the Administration of the President of Russian Federation, Moscow, 121359, Russia

    M. A. Evdokimova, O. Yu. Kudryashova, V. S. Osmolovskaya, L. O. Minushkina, M. S. Kochkina, N. D. Selezneva, E. N. Dankovtseva, O. S. Chumakova, B. A. Sidorenko, D. A. Zateishchikov & V. V. Nosikov

  3. City Hospital no. 17, Moscow, 119620, Russia

    T. N. Baklanova, P. A. Talyzin & N. E. Reznichenko

  4. Clinical Hospital no. 1 of the Administration of the President of Russian Federation, Moscow, 107143, Russia

    O. P. Donetskaya

  5. Moscow State University of Medicine and Dentistry, Moscow, 127473, Russia

    S. N. Tereshchenko, E. S. Krasil’nikova, N. A. Dzhaiani & E. V. Akatova

  6. Sechenov Moscow Medical Academy, Moscow, 119991, Russia

    M. G. Glezer

  7. Kazan State Medical University, Kazan, 420012, Russia

    A. S. Galyavich & V. B. Zakirova

  8. Vagner Perm State Medical Academy, Perm, 614000, Russia

    N. A. Koziolova & I. V. Timofeeva

  9. Stavropol State Medical Academy, Stavropol, 355014, Russia

    A. V. Yagoda & O. I. Boeva

  10. Rostov State Medical University, Rostov, 344022, Russia

    L. I. Katel’nitskaya, E. V. Khorolets & S. V. Shlyk

  11. Chelyabinsk State Medical Academy, Chelyabinsk, 454092, Russia

    E. G. Volkova, M. P. Margaryan & I. O. Guz’

  12. Mechnikov St. Petersburg State Medical Academy, St. Petersburg, 195067, Russia

    V. O. Konstantinov & N. V. Timofeeva

Authors
  1. K. A. Blagodatskikh
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  2. M. A. Evdokimova
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  3. Yu. V. Agapkina
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  4. A. G. Nikitin
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  5. A. N. Brovkin
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  6. A. A. Pushkov
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  7. E. G. Blagodatskikh
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  8. O. Yu. Kudryashova
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  9. V. S. Osmolovskaya
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  10. L. O. Minushkina
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  11. M. S. Kochkina
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  12. N. D. Selezneva
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  13. E. N. Dankovtseva
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  14. O. S. Chumakova
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  18. O. P. Donetskaya
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  19. S. N. Tereshchenko
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  20. E. S. Krasil’nikova
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  24. A. S. Galyavich
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  25. V. B. Zakirova
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  27. I. V. Timofeeva
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  31. E. V. Khorolets
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  33. E. G. Volkova
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  36. V. O. Konstantinov
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  37. N. V. Timofeeva
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  39. D. A. Zateishchikov
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  40. V. V. Nosikov
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Corresponding author

Correspondence to K. A. Blagodatskikh.

Additional information

Original Russian Text © K.A. Blagodatskikh, M.A. Evdokimova, Yu.V. Agapkina, A.G. Nikitin, A.N. Brovkin, A.A. Pushkov, E.G. Blagodatskikh, O.Yu. Kudryashova, V.S. Osmolovskaya, L.O. Minushkina, M.S. Kochkina, N.D. Selezneva, E.N. Dankovtseva, O.S. Chumakova, T.N. Baklanova, P.A. Talyzin, N.E. Reznichenko, O.P. Donetskaya, S.N. Tereshchenko, E.S. Krasil’nikova, N.A. Dzhaiani, E.V. Akatova, M.G. Glezer, A.S. Galyavich, V.B. Zakirova, N.A. Koziolova, I.V. Timofeeva, A.V. Yagoda, O.I. Boeva, L.I. Katel’nitskaya, E.V. Khorolets, S.V. Shlyk, E.G. Volkova, M.P. Margaryan, I.O. Guz’, V.O. Konstantinov, N.V. Timofeeva, B.A. Sidorenko, D.A. Zateishchikov, V.V. Nosikov, 2010, published in Molekulyarnaya Biologiya, 2010, Vol. 44, No. 5, pp. 839–846.

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Blagodatskikh, K.A., Evdokimova, M.A., Agapkina, Y.V. et al. The polymorphisms G(−174)C in IL6 gene and G(−1082)A in IL10 gene are associated with poor outcomes in patients with acute coronary syndrome. Mol Biol 44, 741–747 (2010). https://doi.org/10.1134/S0026893310050092

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