Molecular Biology

, 43:917 | Cite as

Prospects of antisense therapy technologies

  • M. Yu. Skoblov


Three variants of antisense technologies are presently known: antisense oligonucleotides, RNA interference, and ribozymes. In spite of the difference in the mechanisms of action, all of them are based on a common principle: an antisense preparation works after binding with an RNA target to form a duplex. All of the three variants are intensely used in experiments in vivo. The review considers the current situation in the field of using antisense technologies to treat various diseases. Key words: antisense therapy, antisense oligonucleotides, RNA interference, ribozymes


Vascular Endothelial Growth Factor Respiratory Syncytial Virus Antisense Oligonucleotide Transcriptional Gene Silence Antisense Technology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Pleiades Publishing, Ltd. 2009

Authors and Affiliations

  1. 1.Medical Genetic Research CenterRussian Academy of Medical SciencesMoscowRussia

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