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Association of the POLG1 T(−365)C, ANT1 G(−25)A, and PEO1 G(−605)T polymorphisms with diabetic polyneuropathy in patients with Type 1 diabetes mellitus

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Abstract

This study is dedicated to a search for the association of the polymorphic markers T(−365)C of the POLG1 gene G(−25)A of the ANT1 gene and G(−605)T of the PEO1 gene with diabetic polyneuropathy (DPN) in Type 1 diabetes mellitus (DM1) patients. All patients were ethnic Russian Moscow residents, with DM1 records of no more than 5 years and DPN or DM1 records of more than 10 years but without DPN. We found that the polymorphic marker T(−365)C of POLG1 was associated with DPN in Russian patients with DM1. The carriers of the C allele and the CC genotype had a higher risk of DPN development (OR = 1.62; CI = 1.11–2.38; and OR = 1.76; CI = 0.99–3.13; respectively). In contrast, the T allele carrier status and the TT genotype were associated with a lower DPN risk (OR = 0.62, CI = 0.42–0.90; and OR = 0.61; CI = 0.35–1.07; respectively). We found no association of the polymorphic markers G(−25)A of ANT1 or G(−605)T of PEO1 with DPN in Russian DM1 patients living in Moscow.

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Authors and Affiliations

  1. State Research Center GosNIIgenetika, Moscow, 117545, Russia

    E. V. Spitsina, D. A. Chudakova, A. G. Nikitin & V. V. Nosikov

  2. Endocrinology Research Center, Moscow, 117036, Russia

    G. N. Svetlova & T. L. Kurayeva

  3. Sechenov Moscow Medical Academy, Moscow, 119992, Russia

    I. A. Strokov

Authors
  1. E. V. Spitsina
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  2. G. N. Svetlova
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  3. D. A. Chudakova
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  4. A. G. Nikitin
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  5. T. L. Kurayeva
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  6. I. A. Strokov
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  7. V. V. Nosikov
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Correspondence to V. V. Nosikov.

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Original Russian Text © E.V. Spitsina, G.N. Svetlova, D.A. Chudakova, A.G. Nikitin, T.L. Kurayeva, I.A. Strokov, V.V. Nosikov, 2009, published in Molekulyarnaya Biologiya, 2009, Vol. 43, No. 2, pp. 378–382.

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Spitsina, E.V., Svetlova, G.N., Chudakova, D.A. et al. Association of the POLG1 T(−365)C, ANT1 G(−25)A, and PEO1 G(−605)T polymorphisms with diabetic polyneuropathy in patients with Type 1 diabetes mellitus. Mol Biol 43, 348–352 (2009). https://doi.org/10.1134/S0026893309020186

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  • DOI: https://doi.org/10.1134/S0026893309020186

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