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E(y)2, a novel component of the eukaryotic SAGA/TFTC complex, is involved in mRNP export from the nucleus and couples transcription with the nuclear pore

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Abstract

For many years, transcription was studied independently of the following steps of gene expression. A tight connection between different steps of gene expression became evident in recent years. This review discusses the new molecular mechanisms that coordinate transcription and mRNA export from the nucleus and couple transcription and the position of the gene in the nucleus. The new E(y)2 protein, which plays an important role in these processes, is described.

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Authors and Affiliations

  1. Institute of Gene Biology, Russian Academy of Sciences, Moscow, 119334, Russia

    M. M. Kurshakova, E. N. Nabirochkina & S. G. Georgieva

  2. Center for Medical Studies, University of Oslo, Moscow, 119334, Russia

    E. N. Nabirochkina & S. G. Georgieva

  3. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia

    S. G. Georgieva

Authors
  1. M. M. Kurshakova
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  2. E. N. Nabirochkina
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  3. S. G. Georgieva
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Correspondence to M. M. Kurshakova.

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Original Russian Text © M.M. Kurshakova, E.N. Nabirochkina, S.G. Georgieva, 2009, published in Molekulyarnaya Biologiya, 2009, Vol. 43, No. 2, pp. 253–263.

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Kurshakova, M.M., Nabirochkina, E.N. & Georgieva, S.G. E(y)2, a novel component of the eukaryotic SAGA/TFTC complex, is involved in mRNP export from the nucleus and couples transcription with the nuclear pore. Mol Biol 43, 232–240 (2009). https://doi.org/10.1134/S002689330902006X

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  • DOI: https://doi.org/10.1134/S002689330902006X

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