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Prediction of linear B-cell epitopes

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Abstract

The use of antigenicity scales based on physicochemical properties and the sliding window method in combination with an averaging algorithm and subsequent search for the maximum value is the classical method for B-cell epitope prediction. However, recent studies have demonstrated that the best classical methods provide a poor correlation with experimental data. We review both classical and novel algorithms and present our own implementation of the algorithms. The AAPPred software is available at http://www.bioinf.ru/aappred/.

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Authors and Affiliations

  1. Faculty of Biology, Moscow State University, Moscow, 119991, Russia

    Ya. I. Davydov & A. G. Tonevitsky

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  1. Ya. I. Davydov
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  2. A. G. Tonevitsky
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Correspondence to Ya. I. Davydov.

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Original Russian Text © Ya.I. Davydov, A.G. Tonevitsky, 2009, published in Molekulyarnaya Biologiya, 2009, Vol. 43, No. 1, pp. 166–174.

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Davydov, Y.I., Tonevitsky, A.G. Prediction of linear B-cell epitopes. Mol Biol 43, 150–158 (2009). https://doi.org/10.1134/S0026893309010208

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