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Chromosomal localization and molecular organization of the human genomic fragment containing the TNF/LT locus in transgenic mice

  • Genomics. Transcriptomics. Proteomics
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Abstract

The molecular organization, copy number, and chromosome location of the human TNF/LT transgenes were studied in the genomes of two transgenic mouse strains. One strain proved to carry two transgene copies arranged head-to-tail and detected on chromosome 8 by karyotyping. The other strain had one transgene copy observed on chromosome 5. The strains provide a model for studying the physiological functions of the tumor necrosis factor and lymphotoxin.

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Authors and Affiliations

  1. Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, 119991, Russia

    A. R. Galimov, A. A. Kruglov, N. L. Bolsheva, O. Yu. Yurkevich, I. A. Mufazalov, D. V. Kuprash & S. A. Nedospasov

  2. Faculty of Bioengineering and Bioinformatics, Moscow State University, Moscow, 119899, Russia

    A. R. Galimov, A. A. Kruglov & I. A. Mufazalov

  3. Center for Cancer Research, NCI-Frederick, Frederick, Maryland, 21702, USA

    D. Ja. Liepinsh

  4. Belozersky Institute of Physico-Chemical Biology, Moscow State University, Moscow, 199992, Russia

    S. A. Nedospasov

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  1. A. R. Galimov
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  2. A. A. Kruglov
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  3. N. L. Bolsheva
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  4. O. Yu. Yurkevich
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  5. D. Ja. Liepinsh
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  6. I. A. Mufazalov
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  7. D. V. Kuprash
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  8. S. A. Nedospasov
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Correspondence to A. R. Galimov.

Additional information

Original Russian Text © A.R. Galimov, A.A. Kruglov, N.L. Bolsheva, O.Yu. Yurkevich, D.Ja. Liepinsh, I.A. Mufazalov, D.V. Kuprash, S.A. Nedospasov, 2008, published in Molekulyarnaya Biologiya, 2008, Vol. 42, No. 4, pp. 629–638.

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Galimov, A.R., Kruglov, A.A., Bolsheva, N.L. et al. Chromosomal localization and molecular organization of the human genomic fragment containing the TNF/LT locus in transgenic mice. Mol Biol 42, 558–566 (2008). https://doi.org/10.1134/S0026893308040110

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  • DOI: https://doi.org/10.1134/S0026893308040110

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