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Production of proteinases with fibrinolytic and fibrinogenolytic activity by a micromycete Aspergillus ochraceus

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Abstract

Fibrinolytic and fibrinogenolytic activity of surface and submerged cultures of a micromycete Aspergillus ochraceus L-1 was studied. Extracellular proteinases produced by A. ochraceus L-1 were found to exhibit specificity against fibrin and fibrinogen and no activity of plasminogen activators. The highest activity was observed in the cultures grown at 28°С and initial pH 7.0. Fibrinolytic activity was shown to be somewhat above 25% of the total plasmin-like activity of A. ochraceus L-1 proteinases.

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Authors and Affiliations

  1. Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia

    A. A. Osmolovskiy, E. D. Rukavitsyna, V. G. Kreier & N. A. Baranova

  2. Faculty of Biotechnology, Lomonosov Moscow State University, Moscow, Russia

    A. A. Osmolovskiy

  3. International Biotechnological Center, Lomonosov Moscow State University, Moscow, Russia

    N. S. Egorov

Authors
  1. A. A. Osmolovskiy
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  2. E. D. Rukavitsyna
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  3. V. G. Kreier
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  4. N. A. Baranova
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  5. N. S. Egorov
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Corresponding author

Correspondence to A. A. Osmolovskiy.

Additional information

Original Russian Text © A.A. Osmolovskiy, E.D. Rukavitsyna, V.G. Kreier, N.A. Baranova, N.S. Egorov, 2017, published in Mikrobiologiya, 2017, Vol. 86, No. 4, pp. 504–509.

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Osmolovskiy, A.A., Rukavitsyna, E.D., Kreier, V.G. et al. Production of proteinases with fibrinolytic and fibrinogenolytic activity by a micromycete Aspergillus ochraceus . Microbiology 86, 512–516 (2017). https://doi.org/10.1134/S0026261717040105

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  • DOI: https://doi.org/10.1134/S0026261717040105

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