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Efflux systems in Serratia marcescens

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Abstract

A widespread bacterium Serratia marcescens (family Enterobacteriaceae) is an opportunistic pathogen and exhibits multiple drug resistance. Active removal of antibiotics and other antimicrobials from the cells by efflux systems is one of the mechanisms responsible for microbial resistance to these compounds. Among enterobacteria, efflux systems of Escherichia coli and Salmonella enterica ser. Typhimurium have been studied most extensively. Few efflux systems that belong to different families have been reported for S. marcescens. In this review, we analyzed available literature about S. marcescens efflux systems and carried out the comparative analysis of the genes encoding the RND type systems in different Serratia species and in other enterobacteria. Bioinformatical analysis of the S. marcescens genome allowed us to identify the previously unknown efflux systems based on their homology with the relevant E. coli genes. Identification of additional efflux systems in S. marcescens genome will promote our understanding of the physiology of these bacteria, will detect new molecular mechanisms of resistance, and will reveal their resistance potential.

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Abbreviations

MDR:

multiple drug resistance

MFS:

major facilitator superfamily

MATE:

multidrug and toxic compound extrusion family

SMR:

small multidrug resistance family

RND:

resistance-nodulation-cell division superfamily

ORF:

open reading frame

OMP:

outer membrane protein

DAPI:

4′,6-diamino-2-phenylindole

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  1. Kazan (Volga Region) Federal University, ul. Kremlevskaya 18, Kazan, 420008, Russia

    A. M. Mardanova, Yu. D. Romanova & M. R. Sharipova

  2. Texas A&M University, College Station, Texas, UK

    L. M. Bogomol’naya

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Original Russian Text © A.M. Mardanova, L.M. Bogomol’naya, Yu.D. Romanova, M.R. Sharipova, 2014, published in Mikrobiologiya, 2014, Vol. 83, No. 1, pp. 3–14.

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Mardanova, A.M., Bogomol’naya, L.M., Romanova, Y.D. et al. Efflux systems in Serratia marcescens . Microbiology 82, 668–679 (2013). https://doi.org/10.1134/S0026261714010093

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