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Antifungal cellobiose lipid secreted by the epiphytic yeast Pseudozyma graminicola

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Abstract

The yeast Pseudozyma graminicola isolated from plants inhibited growth of almost all ascomycetes and basidiomycetes tested (over 270 species of ca. 100 genera) including pathogenic species. This yeast secreted a fungicidal agent, which was identified as a glycolipid composed of cellobiose residue with two O-substituents (acetyl and 3-hydroxycaproic acid) and 2,15,16-trihydroxypalmitic acid. The release of ATP from the glycolipid-treated cells indicated that this glycolipid impaired the permeability of the cytoplasmic membrane. Basidiomycetes were more sensitive to the cellobiose lipid than ascomycetes.

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Authors and Affiliations

  1. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, pr. Nauki 5, Pushchino, 142290, Russia

    W. I. Golubev, T. V. Kulakovskaya & E. V. Kulakovskaya

  2. Zelinskii Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russia

    A. S. Shashkov

  3. Mendeleev University of Chemical Technology, Moscow, 125820, Russia

    N. V. Golubev

Authors
  1. W. I. Golubev
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  2. T. V. Kulakovskaya
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  3. A. S. Shashkov
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  4. E. V. Kulakovskaya
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  5. N. V. Golubev
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Correspondence to W. I. Golubev.

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Original Russian Text © W.I. Golubev, T.V. Kulakovskaya, A.S. Shashkov, E.V. Kulakovskaya, N.V. Golubev, 2008, published in Mikrobiologiya, 2008, Vol. 77, No. 2, pp. 201–206.

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Golubev, W.I., Kulakovskaya, T.V., Shashkov, A.S. et al. Antifungal cellobiose lipid secreted by the epiphytic yeast Pseudozyma graminicola . Microbiology 77, 171–175 (2008). https://doi.org/10.1134/S0026261708020082

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  • DOI: https://doi.org/10.1134/S0026261708020082

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