Abstract
Environmental stress factors induce oxidative stress in fungi by increasing the intracellular concentrations of reactive oxygen species (ROS). In the mycelium, ROS act as signal molecules needed for cytodifferentiation at certain stages of the development of fungi. Generation of ROS in cells induces the activation of antioxidant protective mechanisms. The purpose of this communication is to analyze the role of ROS in light signal transduction, mediated in Neurospora crassa cells by the White Collar Complex.
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Dröge, W., Free Radicals and Physiological Control of Cell Function, Physiol. Rev., 2002, vol. 82, pp. 47–95.
Hansberg, W. and Aguirre, J., Hyperoxidant States Cause Microbial Cell Differentiation by Cell Isolation from Dioxygen, J. Theor. Biol., 1990, vol. 142, no. 2, pp. 287–293.
Borkovich, K.A., Alex, L.A., Yarden, O., et al., Lessons from the Genome Sequence of Neurospora crassa: Tracing the Path from Genomic Blueprint to Multicellular Organism, Microbiol. Mol. Biol. Rev., 2004, vol. 68, no. 1, pp. 1–108.
Belozerskaya, T.A. and Potapova, T.V., Intrahyphal Communication in Segmented Mycelium, Exp. Mycol., 1993, vol. 17, no. 2, pp. 157–169.
Sokolovskii, V.Yu. and Belozerskaya, T.A., Effect of Stressors on Differential Expression of Genes during Neurospora crassa Development, Usp. Biol. Khim., 2000, vol. 40, pp. 85–152.
Aguirre, J., Rius-Momberg, M., Hewitt, D., and Hansberg, W., Reactive Oxygen Species and Development in Microbial Eukaryotes, Trends Microbiol., 2005, vol. 13, no. 3, pp. 111–118.
Taylor, B.L. and Zhulin, I.B., PAS Domains: Internal Sensors of Oxygen, Redox Potential and Light, Microbiol. Mol. Biol. Rev., 1999, vol. 63, no. 3, pp. 479–506.
Linden, H., White Collar 1 Senses Blue Light, Science, 2002, vol. 297, no. 8, pp. 777–778.
Bloomfield, G. and Pears, C., Superoxide Signaling Required for Multicellular Development of Dictyostellium, J. Cell Sci., 2003, vol. 116, no. 16, pp. 3387–3397.
Sidery, M. and Georgiou, Ch.D., Differentiation and Hydrogen Peroxide Production in Sclerotium rolfsii Are Induced by the Oxidizing Growth Factors, Light and Iron, Mycologia, 2000, vol. 92, no. 6, pp. 1033–1042.
Song, N.-K., Jeong, Ch.-S., and Choi, H.-S., Identification of Nitric Oxide Synthase in Flammulina velutipes, Mycologia, 2000, vol. 92, no. 6, pp. 1027–1032.
Feofilova, E.P., Tereshina, V.M., Memorskaya, A.S., Zav’yalova, L.A., and Maryshova, N.S., Changes in the Cytosol Carbohydrate Composition during the Cytodifferentiation Process in Fungi of the Order Agaricalis, Mikrobiologiya, 1999, vol. 68, no. 3, pp. 356–361 [Microbiology (Engl. Transl.), vol. 68, no. 3, pp. 304–309].
Gessler, N.N., Leonovich, O.A., Rabinovich, Ya.M., Rudchenko, M.N., and Belozerskaya, T.A., A Comparative Study of the Components of the Antioxidant Defense System during Growth of the Mycelium of a Wild-Type Neurospora crassa Strain and Mutants, white collar-1 and white collar-2, Prikl. Biokhim. Mikrobiol., 2006, vol. 42, no. 3, pp. 354–358 [Appl. Biochem. Microbiol. (Engl. Transl.), vol. 42, no. 3, pp. 293–297].
Munkers, K.D., Selection and Analysis of Superoxide Dismutase Mutants of Neurospora crassa, Free Rad. Biol. Chem., 1992, vol. 13, no. 2, pp. 305–318.
Yoshida, Y. and Hasunuma, K., Reactive Oxygen Species Affect Photomorphogenesis in Neurospora crassa, J. Biol. Chem., 2004, vol. 279, no. 8, pp. 6986–6993.
Michan, Sh., Lledias, F., and Hansberg, W., Regulation and Oxidation of Two Large Monofunctional Catalases, Free Rad. Biol. Chem., 2002, vol. 33, no. 4, pp. 521–532.
Winyard, P.J., Mooday, Ch.J., and Jacob, C., Oxidative Activation of Antioxidant Defence, Trends Biochem. Sci., 2005, vol. 30, no. 8, pp. 452–461.
Iigusha, H., Yoshida, Y., and Hasunuma, K., Oxygen and Hydrogen Peroxide Enhance Light-Induced Carotenoid Synthesis in Neurospora crassa, FEBS Lett., 2005, vol. 579, no. 18, pp. 4012–4016.
Michan, Sh., Lledias, F., and Hansberg, W., Asexual Development Is Increased in Neurospora crassa cat-3 Null Mutant Strains, Eukaryotic Cell, 2003, vol. 2, no. 4, pp. 798–808.
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Original Russian Text © T.A. Belozerskaya, N.N. Gessler, 2006, published in Mikrobiologiya, 2006, Vol. 75, No. 4, pp. 497–501.
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Belozerskaya, T.A., Gessler, N.N. Oxidative stress and differentiation in Neurospora crassa . Microbiology 75, 427–431 (2006). https://doi.org/10.1134/S0026261706040102
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DOI: https://doi.org/10.1134/S0026261706040102