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Synthesis, Crystal Structures and Urease Inhibition of Zinc(II) Complexes Derived from 1-(((2-(pyrrolidin-1-yl)ethyl)imino)methyl)Naphthalen-2-ol

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Abstract

Three zinc(II) complexes, [ZnL(μ1,5-dca)]n·nCH3OH (1), [ZnI2(HL)]·CH3OH (2), and [Zn(NCS)4]·2H2L (3), where L, HL and H2L are the monoanionic, zwitterionic, and monocationic forms of the Schiff base 1-(((2-(pyrrolidin-1-yl)ethyl)imino)methyl)naphthalen-2-ol, dca is dicyanamide, have been successfully synthesized and with their components and structures characterized by CHN elemental analyses, infrared and electronic spectroscopy. The detailed structures are further confirmed by single crystal X-ray determination. The Zn atom in the polymeric complex 1 is in square pyramidal coordination, with the phenolate O, imino N and pyrrolidine N atoms of the Schiff base, and one terminal N atom of dca ligand in the basal plane, and with the other terminal N atom of dca ligand at the apical position. The Zn atom in the mononuclear complex 2 is coordinated by the imino N and phenolate O atoms of the Schiff base, and two iodide ligands, forming tetrahedral coordination. The Zn atom in the mononuclear complex 3 is coordinated by four N atoms from four thiocyanate ligands, forming tetrahedral coordination. The Schiff base and their three metal complexes have been tested for their Jack bean urease activity. As a result, complex 2 has the most activity (IC50 = 3.2±1.1 μmol/L).

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Authors and Affiliations

  1. College of Chemical Engineering and Machinery, Eastern Liaoning University, Dandong, People’s Republic of China

    J. Jiang, Y. Deng & H. Zhao

  2. School of Engineering and Technology, Eastern Liaoning University, Dandong, People’s Republic of China

    P. Liang

  3. Department of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian, People’s Republic of China

    Z. You

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Text © The Author(s), 2023, published in Zhurnal Strukturnoi Khimii, 2023, Vol. 64, No. 11, 117920.https://doi.org/10.26902/JSC_id117920

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Jiang, J., Liang, P., Deng, Y. et al. Synthesis, Crystal Structures and Urease Inhibition of Zinc(II) Complexes Derived from 1-(((2-(pyrrolidin-1-yl)ethyl)imino)methyl)Naphthalen-2-ol. J Struct Chem 64, 2099–2110 (2023). https://doi.org/10.1134/S0022476623110070

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