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Structure and Cytotoxic Activity of the Manganese(II) Complex with 5-Methyltetrazole and 4,7-Dimethyl-1,10-Phenanthroline

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Abstract

A novel mononuclear manganese(II) complex with 5-methyltetrazole and 4,7-dimethyl-1,10-phenanthroline is synthesized and characterized by physico-chemical methods (elemental and powder XRD analyses, IR spectroscopy). It is shown by the single-crystal XRD analysis that the coordination environment of the manganese(II) atom is a distorted octahedron. The stability of the complex in an aqueous solution and in phosphate-buffered saline is studied by optical spectroscopy. The cytotoxic activity of the obtained compound is studied on human laryngeal carcinoma cells (Hep-2) and non-cancerous human fibroblasts (MRC-5). The complex exhibits pronounced cytotoxic properties in the studied concentration range: IC50 is 11.1±0.4 µM on the Hep-2 cancer cell line and 0.63±0.05 µM on the MRC-5 line.

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Funding

This work was funded by the Russian Science Foundation (project 20-73-10207).

The study was supported by the Ministry of Science and Higher Education of the Russian Federation (project No. 121031700321-3).

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Authors and Affiliations

  1. Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

    E. A. Ermakova, Yu. A. Golubeva, K. S. Smirnova & E. V. Lider

  2. Institute of Molecular Biology and Biophysics Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia

    L. S. Klyushova

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  1. E. A. Ermakova
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  2. Yu. A. Golubeva
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  3. K. S. Smirnova
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Correspondence to E. V. Lider.

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Russian Text © The Author(s), 2023, published in Zhurnal Strukturnoi Khimii, 2023, Vol. 64, No. 4, 108300.https://doi.org/10.26902/JSC_id108300

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Ermakova, E.A., Golubeva, Y.A., Smirnova, K.S. et al. Structure and Cytotoxic Activity of the Manganese(II) Complex with 5-Methyltetrazole and 4,7-Dimethyl-1,10-Phenanthroline. J Struct Chem 64, 540–549 (2023). https://doi.org/10.1134/S0022476623040029

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  • DOI: https://doi.org/10.1134/S0022476623040029

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