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Syntheses and Crystal Structures of Copper(II) and Zinc(II) Complexes Derived from 5-Bromo-2-((Cyclopropylimino)Methyl)Phenol with Antibacterial Activity

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Abstract

Four new complexes of copper(II) and zinc(II), [Cu2L4] (1), [Cu2L2(N(CN)2)2]n (2), [Zn(HL)2I2] (3) and [Zn(HL)2(NCS)2] (4), where L is 5-bromo-2-((cyclopropylimino)methyl)phenolate, HL is the zwitterionic form of 5-bromo-2-((cyclopropylimino)methyl)phenol, were synthesized and characterized by elemental analysis and IR and UV-Vis spectroscopy. Structures of the complexes were further confirmed by single crystal X-ray structure determination. Complex 1 is a phenolate bridged dinuclear copper(II) compound, with the Cu atom in square pyramidal coordination. Complex 2 is a phenolate and dicyanamide bridged polynuclear copper(II) compound, with the Cu atom in square pyramidal coordination. Complexes 3 and 4 are mononuclear zinc(II) compounds, with the Zn atoms in tetrahedral coordination. The compounds were assayed for their antimicrobial activities. Complexes 1 and 2 have the most activities on B. subtilis, with MIC values of 1.2 μg/mL.

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This work was financially supported by Ningbo Public Welfare Funds (Project Nos. 202002N3056 and 2021S142).

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  1. College of Science and Technology, Ningbo University, Ningbo, People’s Republic of China

    M. Li & X.-Y. Qiu

  2. Department of Basic Theory of Chinese Medicine, Anhui University of Chinese Medicine, Hefei, People’s Republic of China

    Z.-X. Zheng & Y.-J. Wu

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Text © The Author(s), 2023, published in Zhurnal Strukturnoi Khimii, 2023, Vol. 64, No. 3, 106829.https://doi.org/10.26902/JSC_id106829

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Li, M., Qiu, XY., Zheng, ZX. et al. Syntheses and Crystal Structures of Copper(II) and Zinc(II) Complexes Derived from 5-Bromo-2-((Cyclopropylimino)Methyl)Phenol with Antibacterial Activity. J Struct Chem 64, 347–364 (2023). https://doi.org/10.1134/S0022476623030022

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