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SYNTHESIS AND CRYSTAL STRUCTURE OF N-ETHYL-N-CYTISINOCARBOTHIOAMIDE

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Abstract

Based on (–)-cytisine alkaloid and ethyl isothiocyanate, N-ethyl-N-cytisinocarbothioamide is synthesized and its structure is proved by 1H NMR spectroscopy and single crystal X-ray diffraction. The mesomeric effect is shown in the carbothioamide group formed. It is found that π-conjugation between nitrogen atoms and the thiocarbonyl group is weakened due to the steric hindrance between hydrogen atoms of the piperidine ring and the thioamide group.

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Funding

The work was performed within program targeted support No. BR10965230 of the Ministry of Education and Science of the Republic of Kazakhstan.

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Authors and Affiliations

  1. Buketov Karaganda State University, Karaganda, Republic of Kazakhstan

    K. M. Turdybekov & Zh. B. Satpaeva

  2. Institute of Organic Synthesis and Coal Chemistry of the Republic of Kazakhstan, Karaganda, Republic of Kazakhstan

    O. A. Nurkenov & S. D. Fazylov

  3. Karaganda State Technical University, Karaganda, Republic of Kazakhstan

    O. A. Nurkenov & D. M. Turdybekov

Authors
  1. K. M. Turdybekov
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  2. O. A. Nurkenov
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  3. D. M. Turdybekov
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  4. Zh. B. Satpaeva
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  5. S. D. Fazylov
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Corresponding author

Correspondence to K. M. Turdybekov.

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The authors declare that they have no conflict of interests.

Additional information

Russian Text © The Author(s), 2021, published in Zhurnal Strukturnoi Khimii, 2021, Vol. 62, No. 11, pp. 1791-1796.https://doi.org/10.26902/JSC_id81677

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Turdybekov, K.M., Nurkenov, O.A., Turdybekov, D.M. et al. SYNTHESIS AND CRYSTAL STRUCTURE OF N-ETHYL-N-CYTISINOCARBOTHIOAMIDE. J Struct Chem 62, 1678–1683 (2021). https://doi.org/10.1134/S0022476621110032

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  • DOI: https://doi.org/10.1134/S0022476621110032

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