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TREATMENT ACTIVITY AND NURSING VALUES OF A HETEROCYCLIC COMPOUND COMBINED WITH ASPIRIN ON TRAUMATIC ARTHRITIS

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Abstract

Heterocyclic compound 2-(3-(ethoxycarbonyl)-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid (1) designed using 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid (2, Febuxostat) as a starting material is successfully prepared via a multistage synthesis route and finally characterized by IR,1H NMR, and single crystal X-ray diffraction. Its treatment activity combined with aspirin on traumatic arthritis is evaluated along with the related mechanism. Firstly, the ELISA detection is conducted to determine the inflammatory response released into the joint cavity secretion. Additionally, real time RT-PCR is measured and the activation levels of NF-κb are determined after the indicated treatment.

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Authors and Affiliations

  1. Department of Central Supply, Jinan People′s Hospital Affiliated to Shandong First Medical University, Jinan, People’s Republic of China

    J. Xu, Y. Li & L. Wang

  2. Department of Radiology, Jinan People′s Hospital Affiliated to Shandong First Medical University, Jinan, People’s Republic of China

    X. Zhao

  3. Department of Neurosurgery, Jinan People′s Hospital Affiliated to Shandong First Medical University, Jinan, People’s Republic of China

    H. Yang

Authors
  1. J. Xu
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  2. Y. Li
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  3. X. Zhao
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  4. H. Yang
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  5. L. Wang
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Correspondence to J. Xu.

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Text © The Author(s), 2021, published in Zhurnal Strukturnoi Khimii, 2021, Vol. 62, No. 10, pp. 1667-1672.https://doi.org/10.26902/JSC_id80779

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Xu, J., Li, Y., Zhao, X. et al. TREATMENT ACTIVITY AND NURSING VALUES OF A HETEROCYCLIC COMPOUND COMBINED WITH ASPIRIN ON TRAUMATIC ARTHRITIS. J Struct Chem 62, 1563–1568 (2021). https://doi.org/10.1134/S0022476621100103

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  • DOI: https://doi.org/10.1134/S0022476621100103

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