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SYNTHESIS AND ANTICANCER ACTIVITY AGAINST RETINOBLASTOMA OF NOVEL Zn(II) AND Co(II) COMPLEXES

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Abstract

A binucleating Schiff base ligand 2-methoxy-6-(iminomethyl)phenol (HL) and two new M(II) complexes [Zn4L4(N3)4](H2O)2 (1) and [Co4L4Cl4] (2) are synthesized. These metal complexes are characterized using various physicochemical techniques, e.g. elemental analyses and single crystal X-ray diffraction. Furthermore, both CCK-8 assay and cell colony formation results indicate that the inhibitory activity of compound 1 against Y79 retinoblastoma cancer cells is stronger than that of compound 2. In addition to this, we also reveal that compound 1 can significantly increase the ROS accumulation in Y79 retinoblastoma cancer cells, which is higher than that in the group treated with compound 2. All the results above suggest a stronger anticancer activity of compound 1 compared to compound 2 and that it has the potential of being a novel candidate for retinoblastoma cancer treatment.

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Authors and Affiliations

  1. Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, People’s Republic of China

    H. Huang & H. -R. Li

  2. Xi′an Hospital of Traditional Chinese Medicine, Xi′an, Shaanxi, People’s Republic of China

    Y. -Y. Li

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  1. H. Huang
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  2. Y. -Y. Li
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  3. H. -R. Li
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Text © The Author(s), 2021, published in Zhurnal Strukturnoi Khimii, 2021, Vol. 62, No. 9, pp. 1563-1570.https://doi.org/10.26902/JSC_id79952

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Huang, H., Li, Y.Y. & Li, H.R. SYNTHESIS AND ANTICANCER ACTIVITY AGAINST RETINOBLASTOMA OF NOVEL Zn(II) AND Co(II) COMPLEXES. J Struct Chem 62, 1464–1471 (2021). https://doi.org/10.1134/S002247662109016X

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