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SYNTHESIS, CRYSTAL STRUCTURE, AND ANTICANCER ACTIVITY AGAINST THE HeLa CELL LINE OF A NOVEL Co(II) COMPLEX WITH 4,5-BIS(PYRAZOL-1-YL) PHTHALIC ACID

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Abstract

A new complex Co(L)2·2H2O [L = 4,5-bis(pyrazol-1-yl)phthalic acid] is synthesized and characterized by single crystal X-ray diffraction and elemental analysis. The complex is H bonded to form a 1D chain structure. It can further stretched to a 2D layered structure through the π–π stacking interaction. The ability of the complex to interact with DNA is studied by fluorescence spectroscopy. Fluorescence demonstrates that the complex is able to bind DNA. Apoptosis studies show that the complex has a significant ability to induce apoptosis of tumor cells. Flow cytometry indicate that the complex exhibits a significant cancer cell inhibitory rate.

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Funding

We sincerely acknowledge the Natural Science Foundation of China (Nos. U1608224 and 21171118), the Distinguished Professor Project of Liaoning province, Liao Ning Revitalization Talents Program (XLYC1907047), and the Department of Education Basic Research Project of Liaoning Provincial (LJ2019010).

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Authors and Affiliations

  1. Key Laboratory of Liaoning Inorganic Molecule-Based Chemical and Department of Coordination Chemistry, Shenyang University of Chemical Technology, Shenyang, People’s Republic of China

    M. Zhu, J. Wang, S. Wu & E. Gao

  2. School of Chemical Engineering, University of Science and Technology Liaoning, Anshan, People’s Republic of China

    E. Gao

  3. Key Laboratory of Resource Chemical Technology and Materials (Ministry of Education), Shenyang University of Chemical Technology, Shenyang, People’s Republic of China

    M. Zhu

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  1. M. Zhu
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  2. J. Wang
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  3. S. Wu
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  4. E. Gao
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Correspondence to E. Gao.

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The authors declare that they have no conflict of interests.

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Published in Zhurnal Strukturnoi Khimii, 2021, Vol. 62, No. 2, pp. 258-264 https://doi.org/10.26902/JSC_id69547 .

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Zhu, M., Wang, J., Wu, S. et al. SYNTHESIS, CRYSTAL STRUCTURE, AND ANTICANCER ACTIVITY AGAINST THE HeLa CELL LINE OF A NOVEL Co(II) COMPLEX WITH 4,5-BIS(PYRAZOL-1-YL) PHTHALIC ACID. J Struct Chem 62, 244–250 (2021). https://doi.org/10.1134/S0022476621020086

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  • DOI: https://doi.org/10.1134/S0022476621020086

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